PER-1 extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa clinical isolates from Budapest, Hungary, and Belgrade, Serbia, were characterized by molecular methods. Two PER-1-positive isolates were recovered from sporadic cases in Budapest and a small cluster of PER-1-positive infections involving four patients were identified at a Belgrade hospital. A class 1 integron harbouring a bla(OXA-2)beta-lactamase gene and four other gene cassettes was detected in both the Budapest and the Belgrade isolates. The two P. aeruginosa isolates from Budapest also carried another class 1 integron containing bla(OXA-74), aac(6')-Ib-cr and cmlA7 genes in its variable region. The aac(6')-Ib-cr fluoroquinolone-acetylating aminoglycoside acetyltransferase gene is described here for the first time in P. aeruginosa. Multilocus sequence typing (MLST) revealed that the PER-1 positive P. aeruginosa isolates identified in this study display ST235, a sequence type that belongs to clonal complex CC11. Two bla(PER-1)-positive P. aeruginosa reference isolates from France and Belgium could also be assigned to complex CC11 by MLST. Our results underscore the role of complex CC11 in the dissemination of bla(PER-1) among P. aeruginosa clinical isolates.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1574-695X.2008.00483.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of Genetic Determinants Encoding Resistance to Heavy Metals and Disinfectants in .
Foods
December 2024
Department of Food Safety, National Institute of Public Health NIH-National Research Institute, 24 Chocimska str, 00-791 Warsaw, Poland.
is an important foodborne pathogen causing listeriosis. , existing in the natural environment, can also contaminate food products, which poses a serious threat to human health and life, especially for high-risk groups: pregnant women, newborn babies, and the elderly. Environmental adaptation of refers to the various strategies and mechanisms used by this bacterium to survive and thrive in diverse and often hostile environments that include, among others, toxic heavy metals and disinfectants.
View Article and Find Full Text PDFEpidemiology of invasive meningococcal disease, Japan, 2013 to 2023.
Euro Surveill
November 2024
Center for Field Epidemic Intelligence, Research and Professional Development, National Institute of Infectious Diseases, Tokyo, Japan.
Article Synopsis
- * Over the last decade, 274 IMD cases were reported, predominantly in older males, with an overall low incidence rate and no outbreaks linked to mass gatherings.
- * The incidence of IMD in Japan is low compared to higher incidence countries, with a significant decline noted post-2020; the predominance of serogroup Y and the importance of continued surveillance for effective disease management were highlighted.
High-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits.
mBio
December 2024
Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Article Synopsis
- Genome-wide association studies (GWAS) have effectively identified disease-related genetic markers and antimicrobial resistance factors in bacterial pathogens, using a new phenotype-to-genotype approach to analyze multiple traits simultaneously.
- Researchers examined 163 specific bacterial isolates for 11 traits, revealing significant differences in eight traits between disease subgroups and candidate genes linked to survival advantages.
- The study highlights the importance of integrating high-throughput phenotypic testing with genomic analysis, successfully identifying key genetic determinants that contribute to the behavior and pathogenicity of bacterial pathogens.
Clinical and Bacterial Characteristics of Bloodstream Infections Caused by in Western China.
Can J Infect Dis Med Microbiol
September 2024
Department of Laboratory Medicine West China Hospital Sichuan University, Chengdu 610041, Sichuan, China.
Article Synopsis
- Bloodstream infections (BSIs) show a high in-hospital mortality rate of 25.7%, with changes in consciousness and elevated serum C-reactive protein (CRP) levels identified as key factors in diagnosis.
- Analysis of 27 isolated strains found that they were mostly susceptible to common antibiotics, but only 22.2% were responsive to trimethoprim-sulfamethoxazole, indicating potential treatment challenges.
- Genetic testing revealed a variety of sequence types and clonal complexes among the strains, with the predominance of specific genotypes, highlighting the need for vigilance in monitoring the spread of these virulent strains.
Genomic Surveillance of Invasive Meningococcal Disease During a National MenW Outbreak in Australia, 2017-2018.
Open Forum Infect Dis
June 2024
Microbiological Diagnostic Unit Public Health Laboratory at The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
Article Synopsis
- Invasive meningococcal disease (IMD) rates surged in Australia from 2014 to 2017, largely due to rising infections from serogroups W and Y, prompting a study on genetic diversity in 2017 and 2018 using whole genome sequencing.
- The study analyzed 440 Australian IMD isolates and 1737 international MenW:CC11 isolates, revealing that MenW, MenB, and MenY were the most common serogroups and identified 18 clonal complexes, with three (CC11, CC23, CC41/44) making up 78% of the isolates.
- Findings showed that while MenB isolates were highly diverse, MenW and MenC were less
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!