AI Article Synopsis
- 3,6-Dichloropyridazine can be efficiently metallated using a specific zinc-magnesium-lithium complex.
- The resulting bis-organozinc compound reacts well with a variety of electrophiles, allowing for further chemical modifications.
- Subsequent reactions with hydrazine produce complex and highly substituted derivatives known as pyrazolo[3,4-c]pyridazines.
Article Abstract
3,6-Dichloropyridazine undergoes a smooth metallation using (tmp)2Zn.2MgCl2.2LiCl. The resulting bis-organozinc species react with various electrophiles; subsequent functionalization via a second metallation proceeds readily; further reactions with hydrazine lead to highly substituted pyrazolo[3,4-c]pyridazines derivatives.
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| http://dx.doi.org/10.1039/b815903c | DOI Listing |
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