We have examined the effects of the muscarinic antagonist atropine, on non-receptor-mediated activation of intracellular calcium (Ca2+i) mobilization events. In dispersed rat parotid acini, atropine significantly lowered basal inositol trisphosphate levels and delayed AlF4(-)-stimulated Ca2+i elevation in a dose-dependent manner. In a cell line transfected with the m1 muscarinic receptor (M1-CHO), atropine significantly lowered (approximately 60%) AlF4- stimulated Ca2+i elevation. These aggregate findings suggest that atropine, acting via the muscarinic receptor, decreases the efficacy of G protein-mediated activation of phospholipase C.
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| http://dx.doi.org/10.1016/0006-291x(91)91857-9 | DOI Listing |
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