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Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue.
BMC Public Health
December 2024
School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Objectives: To identify the cost-effectiveness of four policy options related to folic acid supplements after considering the side effects of masking vitamin B12 (B12) deficiency in primary stroke prevention for hypertensive patients in China.
Study Design: A cost-effectiveness analysis.
Methods: Four policies were considered: Policy A, Do nothing to address folate status in hypertensive patients at risk for stroke; Policy B, Folate supplementation without pre-screening for vitamin B12 deficiency; Policy C, Folate supplementation with pre-screening all patients for B12 deficiency and add B12 supplements if B12 is deficient; and Policy D, Folate supplementation only for those whose folate is deficient, pre-screen all patients for both B12 and folate deficiencies and add B12 supplements if B12 is deficient.
A review on methods for the production of microcapsules and their application in drug and food technology.
Polim Med
December 2024
Department of Physical Chemistry and Biophysics, Faculty of Pharmacy, Wroclaw Medical University, Poland.
Microencapsulation is a technology for encapsulating particles in a coating designed to isolate the core substance from external conditions, including oxidation, UV radiation or humidity. Microcapsules reach dimensions of up to 5,000 μm. In the pharmaceutical industry, they are used for the controlled release of active substances, masking their taste, odor or gastrointestinal irritation, and can also reduce the toxicity of some medicinal substances.
View Article and Find Full Text PDFThe effect of vitamin D supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial.
Diabetologia
December 2024
University of Eastern Finland, Institute of Public Health and Clinical Nutrition, Kuopio, Finland.
Aims/hypothesis: Vitamin D insufficiency is associated with an elevated risk of type 2 diabetes, but evidence from randomised trials on the benefits of vitamin D supplementation is limited, especially for average-risk populations. The Finnish Vitamin D Trial (FIND) investigated the effects of vitamin D supplementation at two different doses on the incidence of type 2 diabetes in a generally healthy older adult population.
Methods: FIND was a 5 year randomised placebo-controlled, parallel-arm trial among 2271 male and female participants aged ≥60 years and ≥65 years, respectively, from a general Finnish population who were free of CVD or cancer and did not use diabetes medications.
Bilateral Stress Fractures of Amputated Tibial Stumps in the Setting of Chronic Compartment Syndrome.
Orthop Res Rev
November 2024
Scientific Department, Scientific and Research Institute of Rehabilitation of National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
Introduction: Limb amputation and subsequent prosthetics lead to significant disturbances in bone residual limb remodeling.
Aim: To familiarize specialists with the possibility of simultaneous bilateral stress fractures of amputation residual limbs resulting from intensive loads and poor-quality prosthetics causing chronic compartment syndrome. A case of bilateral stress fractures of the tibia in a 28-year-old male military serviceman with paired transtibial amputation is presented.
Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability.
Int J Pharm
December 2024
Department of clinical pharmacy, Gustave Roussy Cancer Campus, Villejuif 94800, France; Université Paris-Saclay, CNRS, Institut des Sciences Moléculaires d'Orsay, Orsay 91405, France.
Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood-brain barrier with effective therapies. ONC201 (dordaviprone) shows promises in inducing apoptosis in cancer cells but suffers from poor water solubility and stability issues. Moreover, conventional solubilizing agents acceptable in formulations intended for adult patients are not suitable for pediatric use.
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