Regulatory T cells have an important role in limiting immune reactions and are essential regulators of self-tolerance. Among them, CD4+CD25high regulatory T cells are the best-described subset. In this article, we summarize current knowledge on the phenotype, function, and development of CD4+CD25high regulatory T cells. We also review the literature on the role of these T cells in rheumatic diseases and discuss the potential for their use in immunotherapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633304 | PMC |
| http://dx.doi.org/10.1186/1546-0096-6-20 | DOI Listing |
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