The potential of mean force between two spherical and like-charged macroions in a salt-free aqueous solution has been determined using an extended primitive model and canonical Monte Carlo simulations. The systems considered covered the range from a purely repulsive to a purely attractive potential of mean force as the electrostatic coupling was increased. The macroions were modeled as spherical dielectric cavities, and the polarization surface charge densities occurring at the dielectric discontinuities were expanded in spherical harmonics. The surface polarization gave rise to (i) an attenuation of the counterion accumulation at the macroion surfaces at all cases considered, (ii) an enhanced repulsive potential of mean force in the weak to intermediate electrostatic coupling regime, and (iii) a less attractive at short separation and an enhanced attractive potential of mean force at longer macroion-macroion separation in the strong electrostatic coupling regime.
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http://dx.doi.org/10.1063/1.2971038 | DOI Listing |
Integr Comp Biol
January 2025
Department of Biology, Henson School of Science and Technology, Salisbury University, Salisbury, MD 21801, USA.
The mucus coating around a fish's body is essential to its survival. It contains antimicrobial properties, aids in drag reduction, and protects against physical damage. It is versatile in the aquatic environment but little is known about the role of mucus in amphibious fishes.
View Article and Find Full Text PDFJ Neurosci
January 2025
Carney Institute for Brain Science, Brown University, Providence, RI 02912
The neuromuscular junction (NMJ) is the linchpin of nerve-evoked muscle contraction. Broadly, the function of the NMJ is to transduce nerve action potentials into muscle fiber action potentials (MFAPs). Efficient neuromuscular transmission requires both cholinergic signaling, responsible for generation of endplate potentials (EPPs), and excitation, the amplification of the EPP by postsynaptic voltage-gated sodium channels (Nav1.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Urology, Affiliated Hospital of Youjiang Medical University for Nationalities and Key Laboratory of Molecular Pathology in Tumors of Baise, Baise 533000, China. Electronic address:
The primary objective of this study was to conduct a comprehensive analysis of the mechanism by which TCF7 recombinant protein operates, as well as to examine its expression patterns within bladder cancer cells. This research seeks to establish a new theoretical framework and provide experimental data that could advance the field of molecular targeted therapy for bladder cancer. Erlotinib, a well-known targeted therapy drug, was administered to the bladder cancer cells, and we evaluated its antitumor effects through various assays such as cell proliferation, apoptosis, and cell cycle analysis.
View Article and Find Full Text PDFJ Endod
January 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Cariology and Endodontics, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address:
Introduction: Fiber posts present significant challenges for nonsurgical endodontic retreatment, as improper removal may result in iatrogenic root perforation or even root fracture. Recently, robotic technology has attracted considerable attention in dentistry and active dental robotic (ADR) systems can perform procedures based on preset instructions, minimizing reliance on the dentist's experience. This case report describes the application of an ADR system for fiber post removal through an existing zirconia crown.
View Article and Find Full Text PDFAdv Colloid Interface Sci
January 2025
Department of Chemistry and Biotechnology, School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Melbourne, Australia.
In the evolving landscape of nanotechnology and pharmaceuticals, lipid nanostructures have emerged as pivotal areas of research due to their unique ability to mimic biological membranes and encapsulate active molecules. These nanostructures offer promising avenues for drug delivery, vaccine development, and diagnostic applications. This comprehensive review explores the complex mechanisms underlying the formation and stability of various lipid nanostructures, including lipid liquid crystalline nanoparticles and solid lipid nanoparticles.
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