Understanding mix in inertial confinement fusion (ICF) experiments at the National Ignition Facility requires the diagnosis of charged-particle reactions within an imploded target. Radiochemical diagnostics of these reactions are currently under study by scientists at Los Alamos and Lawrence Livermore National Laboratories. Measurement of these reactions requires assay of activated debris and tracer gases from the target. Presented below is an overview of the prompt radiochemistry diagnostic development efforts, including a discussion of the reactions of interest as well as the progress being made to collect and count activated material.
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http://dx.doi.org/10.1063/1.2972174 | DOI Listing |
Nucl Med Biol
September 2024
Westinghouse Electric Company LLC, 1000 Westinghouse Drive, Cranberry Township, PA 16066, United States of America.
Background: Actinium-225 is one of the most promising radionuclides for targeted alpha therapy. Its limited availability significantly restricts clinical trials and potential applications of Ac-based radiopharmaceuticals.
Methods: In this work, we examine the possibility of Ac production from the thermal neutron flux of a nuclear reactor.
Bioconjug Chem
November 2023
GDMPA Key Laboratory for Quality Control and Evaluation of Radiopharmaceuticals, PET Center and Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Molecular imaging and targeted radiotherapy with radiolabeled fibroblast activation protein inhibitor (FAPI) targeting peptide probes hold great potential for enhancing the clinical management of patients with FAP-expressing cancers. However, the high cost of PET probes has prompted us to search for new FAP-targeting single-photon imaging agents. In this study, HYNIC-Glc-FAPT is synthesized and radiolabeled with technetium-99m using tricine/EDDA or dimer tricine as coligands to produce [Tc]Tc-tricine/EDDA-HYNIC-Glc-FAPT and [Tc]Tc-tricine-HYNIC-Glc-FAPT.
View Article and Find Full Text PDFAnal Chim Acta
July 2023
Radiochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India; Homi Bhabha National Institute, Department of Atomic Energy, Anushaktinagar, Mumbai, 400094, India. Electronic address:
Beam current monitoring and normalization is a very important task in ion beam analysis experiments. Compared to current monitoring by conventional method, in situ or external beam current normalization is attractive in Particle Induced Gamma-ray Emission (PIGE), which involves simultaneous measurement of prompt gamma rays of analyte of interest and current normalizing element. In the present work, an external (in air) PIGE method has been standardized for quantification of low Z elements using nitrogen from atmospheric air as external current normalizer, in which 2313 keV of N(p,p'γ)N is measured.
View Article and Find Full Text PDFJ Chem Inf Model
January 2023
Department of Chemistry, Bar-Ilan University, Ramat-Gan5290002, Israel.
Glass fragments found in crime scenes may constitute important forensic evidence when properly analyzed, for example, to determine their origin. This analysis could be greatly helped by having a large and diverse database of glass fragments and by using it for constructing reliable machine learning (ML)-based glass classification models. Ideally, the samples that make up this database should be analyzed by a single accurate and standardized analytical technique.
View Article and Find Full Text PDFRSC Adv
November 2022
Radiochemistry Division, Bhabha Atomic Research Centre Trombay Mumbai-400085 India
External (in air) PIGE methodology has been optimized for rapid quantification of fluorine, sodium, and phosphorus in fluorapatite waste immobilization matrices for Molten Salt Reactor (MSR). The present methodology addresses the issue of distinguishing hydroxyapatite and fluorapatite phases through XRD patterns. Fluctuations in proton beam current have been monitored by prompt γ-ray from nitrogen (2312 keV) through N(p,p'γ)N nuclear reaction and have successfully been applied as a new method of current normalization, for the first time, in external PIGE method with lower Compton background and negligible spectral interference.
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