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Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth.
Colloids Surf B Biointerfaces
March 2025
Department of Medical and Translational Biology, Umeå University, Umeå SE-901 87, Sweden. Electronic address:
Quercetin, a flavonoid known for its antioxidant properties, has recently garnered attention as a potential neuroprotective agent for treatment of the injured nervous system. The repair of peripheral nerve injuries hinges on the proliferation and migration of Schwann cells, which play a crucial role in supporting axonal growth and myelination. In this study we synthesized Quercetin-derived carbon dots (QCDs) and investigated their effects on cultured Schwann cells and the NG108-15 cell line.
View Article and Find Full Text PDFAmniotic membrane hydrogel as novel injectable platform in combination with metformin for treatment of sciatic nerve injury.
J Appl Biomater Funct Mater
March 2025
Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Peripheral nerve tissue engineering is a field that uses cells, growth factors and biological scaffold material to provide a nutritional and physical support in the repair of nerve injuries. The specific properties of injectable human amniotic membrane-derived hydrogel including growth factors as well as anti-inflammatory and neuroprotective agents make it an ideal tool for nerve tissue repair, and metformin may also aid in nerve regeneration. The aim of this study was to investigate the effects of hydrogel derived from amniotic membrane (AM) along with metformin (MET) administration in the repair of sciatic nerve injury in male rats.
View Article and Find Full Text PDFMultifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway.
Mater Today Bio
April 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Diabetic infected bone defect remains a great challenge in clinical practice, with delayed healing characterized by bacterial infection and cellular disfunction caused by oxidative stress. Hence, a novel self-healing multifunctional Ag@PEG-4OI/EXO hydrogel is introduced for improving healing of diabetic infected bone defect. 4-octyl itaconate, a derivative of the metabolite itaconate, has been proved that which performs antioxidant and mitochondria-protected properties.
View Article and Find Full Text PDFAminophenol Molecular Capture Layer for Specific Molecular Sensing with Field-Effect Devices.
ACS Appl Mater Interfaces
March 2025
School of Electrical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
There is an urgent need today for interface management with recognition layers composed of short receptor molecules, with excellent specificity and affinity toward a target molecule, for a wide range of sensing applications. The current work demonstrates a specific detection of a G-type nerve agent, which is based on a nucleophilic substitution reaction between the surface-bound 4-amino-2-((dimethylamino)methyl)phenol (amino-2-DMAMP) receptors and the diethyl chlorophosphate (DCP) simulant. The specificity and affinity of 2-DMAMP toward DCP are demonstrated with P-nuclear magnetic resonance (NMR) and electrospray ionization mass spectrometry (ESI-MS/MS).
View Article and Find Full Text PDFDescription of Heterorhabditis americana n. sp. (Rhabditida, Heterorhabditidae), a new entomopathogenic nematode species isolated in North America.
Parasit Vectors
March 2025
Plant Genetics Research Unit, United States Department of Agriculture (USDA)-Agricultural Research Service, Columbia, MO, USA.
Background: Heterorhabditis are important biological control agents in agriculture. Two Heterorhabditis populations, S8 and S10, were isolated from agricultural soils in the United States of America. Molecular analyses, based on mitochondrial and nuclear genes, showed that these populations are conspecific and represent a novel species of the "Bacteriophora" clade.
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