In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously considered unviable as drugs. HME is considered to be an efficient technique in developing solid molecular dispersions and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. This article reviews the range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration. Interest in HME as a pharmaceutical process continues to grow and the potential of automation and reduction of capital investment and labor costs have made this technique worthy of consideration as a drug delivery solution.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821067 | PMC |
| http://dx.doi.org/10.1517/17425240802583421 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictors of Radiation Resistance and Novel Radiation Sensitizers in Head and Neck Cancers: Advancing Radiotherapy Efficacy.
Semin Radiat Oncol
April 2025
Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.. Electronic address:
Radiation resistance in head and neck squamous cell carcinoma (HNSCC), driven by intrinsic and extrinsic factors, poses a significant challenge in radiation oncology. The key contributors are tumor hypoxia, cancer stem cells, cell cycle checkpoint activation, and DNA repair processes (homologous recombination and non-homologous end-joining). Genetic modifications such as TP53 mutations, KRAS mutations, EGFR overexpression, and abnormalities in DNA repair proteins like BRCA1/2 additionally affect radiation sensitivity.
View Article and Find Full Text PDFMicro/nanomotors in targeted drug delivery: Advances, challenges, and future directions.
Int J Pharm
March 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, China; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430079 Wuhan, China. Electronic address:
The therapeutic efficacy of drugs is highly dependent on their successful delivery to the target site. However, achieving targeted drug delivery to diseased areas remains a significant challenge. Current drug delivery systems based on nanocarriers often suffer from inefficiencies due to their lack of intrinsic propulsion and active targeting capabilities.
View Article and Find Full Text PDFHybrid membranes-mediated biomimetic-nanoparticle carrying miR-665 for effective tumor treatment by remodeling tumor microenvironment.
Int J Pharm
March 2025
Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, PR China. Electronic address:
Background: Osteosarcomas (OS) are malignant bone tumors prevalent in adolescents, characterized by aggressiveness and early metastasis. Current treatments including surgery and chemotherapy face challenges due to drug limitations and the complex tumor microenvironment (TME).
Methods: Tumour membranes (TM) derived from OS cells and macrophage membranes (MM) derived from macrophages were mixed to create hybrid membranes (HM), which were subsequently used to encapsulate microRNA-665(miR-665)-loaded Poly lactic-co-glycolic acid (PLGA) nanoparticles, forming HM@PLGA/miR-665 complexes.
DNA as a Promising Biomaterial for Bone Regeneration and Potential Mechanisms of Action.
Acta Biomater
March 2025
Faculty of Dentistry, University of Toronto, Toronto, Canada, 124 Edward Street, Toronto, ON, M5G 1G6, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Canada, 164 College St, Toronto, ON, M5S 3G9, Canada. Electronic address:
DNA nanotechnology has created new possibilities for the use of DNA in tissue regeneration - an important advance for DNA use beyond its paradigmatic role as the hereditary biomacromolecule. Biomaterials containing synthetic or natural DNA have been proposed for several applications including drug and gene delivery, and more recently, as osteoconductive biomaterials. This review provides an in-depth discussion of studies that have used DNA-based materials for biomineralization and/or bone repair, with expansion on the topic of DNA hydrogels specifically, and the advantages they offer for advancing the field of bone regeneration.
View Article and Find Full Text PDFChemotoxic and phototoxic effects of liposomal co-delivery of green synthesized silver nanoparticles and ZnPcS for enhanced photodynamic therapy in MCF-7 breast cancer cells: An in vitro study.
Biomed Pharmacother
March 2025
Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, South Africa. Electronic address:
Breast cancer remains a significant challenge in oncology, despite notable advances in treatment methods. Traditional therapies such as surgery, chemotherapy, radiation, and hormonal treatments have long been used to manage breast cancer. However, often patients experience treatment failure, resulting in disease recurrence and progression.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!