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In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously considered unviable as drugs. HME is considered to be an efficient technique in developing solid molecular dispersions and has been demonstrated to provide sustained, modified and targeted drug delivery resulting in improved bioavailability. This article reviews the range of HME applications for pharmaceutical dosage forms, such as tablets, capsules, films and implants for drug delivery through oral, transdermal, transmucosal, transungual, as well as other routes of administration. Interest in HME as a pharmaceutical process continues to grow and the potential of automation and reduction of capital investment and labor costs have made this technique worthy of consideration as a drug delivery solution.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821067 | PMC |
http://dx.doi.org/10.1517/17425240802583421 | DOI Listing |
Biotechnol Biofuels Bioprod
March 2025
Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
The growing demand for sustainable and eco-friendly alternatives in bioprocessing, healthcare, and manufacturing has stimulated significant interest in Bacillus subtilis surface display technology. This innovative platform, leveraging both spore and vegetative cell forms, provides exceptional versatility for a wide spectrum of applications, spanning from green technologies to advanced biomedical innovations. The robustness of spores and the metabolic activity of vegetative cells enable efficient enzyme immobilization, biocatalysis, and biosensor development, facilitating bioremediation, pollutant degradation, and renewable energy generation.
View Article and Find Full Text PDFDrug Deliv Transl Res
March 2025
State Key Laboratories for Quality Research in Chinese Medicines, Faculty of Pharmacy, Macau University of Science and Technology, Macau, 999078, China.
Intracerebral hemorrhage (ICH) is a serious cerebrovascular disease with high morbidity, mortality, and disability rates, largely due to neuroinflammation. Diosmetin, a natural flavonoid, has known neuroprotective effects in cerebral ischemia/reperfusion models but has been less studied in ICH. Our previous study developed diosmetin-loaded lactoferrin-modified long-circulating liposomes (Lf-Dios-Lcl), which penetrate the BBB and improve diosmetin bioavailability and brain distribution.
View Article and Find Full Text PDFSci Rep
March 2025
State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China, 325000.
The modulation of inflammatory mediators has emerged as a critical therapeutic strategy in uveitis management. Current nonsteroidal anti-inflammatory therapies face limitations due to systemic side effects. Caffeic acid (CA), a natural polyphenol with anti-inflammatory properties, holds therapeutic potential but suffers from poor solubility and ocular irritation.
View Article and Find Full Text PDFSci Rep
March 2025
Department of Biological Sciences, University of Africa, Toru-Orua, Bayelsa State, Nigeria.
HIV presents an ongoing, serious issue within the global public health domain, with prevalence across all nations. Mobile health (m-Health) is the use of mobile and wireless devices to improve health outcomes, health care services, and health research has been shown to have the capacity to improve medication adherence. Good adherence to ART is beneficial to patients and the public.
View Article and Find Full Text PDFNat Commun
March 2025
Nano-Optics and Biophotonics Group, Experimentelle Physik 5, Physikalisches Institut, Universität Würzburg, Am Hubland, Würzburg, Germany.
Recently light-driven microdrones have been demonstrated, making use of plasmonic nanomotors based on directional resonant chiral light scattering. These nanomotors can be addressed individually, without requiring the tracking of a focused laser, leading to exceptional 2D maneuverability which renders microdrones a versatile robotic platform in aqueous environments. Here, we incorporate a light-operated manipulator, a plasmonic nano-tweezer, into the microdrone platform, rendering it a microrobot by enabling precise, all-optical transport and delivery of single nanoparticles suspended in solution.
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