Objective: To identify male patients who were treated with infliximab and had fathered healthy newborns during their management.
Methods: We reviewed medical records of men with ankylosing spondylitis (AS) who were followed up at the Rheumatology Outpatients clinic and were treated with infliximab during the period 2001-2007.
Results: We identified 4 patients with AS who had fathered 6 healthy children during infliximab treatment. One patient was also treated with small doses of methotrexate.
Conclusion: Limited data are available concerning the effects of infliximab on semen quality. Our cases provide some evidence or reassurance for male patients treated with the anti-tumor necrosis factor-alpha agent. Further prospective studies are necessary, however, to guide clinicians in decision making.
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