AI Article Synopsis
- Vasohibin-1 is a newly identified inhibitor of angiogenesis, and its role in breast cancer has been studied across 151 breast specimens, showing higher levels in invasive ductal carcinoma (IDC) and inflammatory lesions.
- A significant positive correlation was found between vasohibin-1 and other angiogenic factors like VEGF-A and bFGF, as well as with patient overall and disease-free survival rates.
- Double-immunostaining results indicated that a higher percentage of Ki-67-positive proliferative cells were found among vasohibin-1-positive endothelial cells, suggesting that vasohibin-1 may play a crucial role in regulating blood vessel formation within tumors in breast cancer.
Article Abstract
Vasohibin-1 is a recently identified negative feedback inhibitor or suppressor of angiogenesis induced by vascular endothelial growth factor (VEGF)-A. The status of vasohibin-1 in human breast carcinoma has not been examined. We examined 151 breast specimens including 98 cases of invasive ductal carcinoma (IDC), 12 of ductal carcinoma in situ (DCIS), 16 of fibroadenoma (FA), six of inflammatory lesion, nine of fibrocystic change and seven of non-pathological breast tissue. We immunolocalized vasohibin-1 and compared its immunoreactivity to that of VEGF-A, basic fibroblastic growth factor (bFGF), VEGF receptor 2 (Flk-1), CD31, CD34 and Ki-67/MIB-1. The correlation of vasohibin-1 immunoreactivity with overall survival (OS), and disease-free survival (DFS) of the patients with breast carcinoma was also evaluated. In addition, we evaluated Ki-67 and CD31, and Ki-67 and vasohibin-1 double-immunostaining for further characterization of neovascularization. Vasohibin-1 was detected in endothelial cells of human breast and its immunodensity was significantly higher in IDC and inflammatory lesions than the other types (P<0.001). In addition, a significant positive correlation was detected between vasohibin-1 and VEGF-A, bFGF or Flk-1 (P<0.001). There was also positive associations between vasohibin-1 and OS (P=0.004) and between vasohibin-1 and DFS (P
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159213 PMC http://dx.doi.org/10.1111/j.1349-7006.2008.01015.x DOI Listing Publication Analysis
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