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Genomic epidemiology of ceftriaxone-resistant non-typhoidal Salmonella enterica strain in China.
BMC Genomics
October 2024
Department of Gastroenterology, Sanmen Bay Branch of The First Affiliated Hospital, Sanmen People's Hospital, Zhejiang University School of Medicine, Taizhou, Zhejiang, 317100, China.
Non-typhoidal Salmonella (NTS) is one of the top causes of diarrhea worldwide. Ceftriaxone is commonly recommended as the initial treatment option for Salmonella infections due to its antibacterial effectiveness. The objective of this study was to investigate the molecular epidemiological characteristics of NTS and to compare the phenotypic and genotypic profiles of antimicrobial resistance in multidrug-resistant Salmonella strains by sequencing 329 NTS strains collected from a county-level hospital between 2018 and 2021.
View Article and Find Full Text PDFCeftriaxone-resistant serovar Newport: a case report from South India.
Front Public Health
August 2024
Department of Microbiology, JSS Medical College and Hospital, JSS AHER, Mysuru, India.
serovar Newport is a human pathogen underreported in most developing countries. It is known for causing gastroenteritis and extraintestinal infections. In this case report, we report the case of ceftriaxone-resistant serovar Newport from South India, causing acute gastroenteritis in a sixty-year-old female patient having a history of antimicrobial therapy and recent hospital admission.
View Article and Find Full Text PDFRapid detection of ceftriaxone-resistant Salmonella by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry combined with the ratio of optical density.
Ann Clin Microbiol Antimicrob
August 2024
Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng road, Hangzhou, Zhejiang Province, China.
Background: The increased resistance rate of Salmonella to third-generation cephalosporins represented by ceftriaxone (CRO) may result in the failure of the empirical use of third-generation cephalosporins for the treatment of Salmonella infection in children. The present study was conducted to evaluate a novel method for the rapid detection of CRO-resistant Salmonella (CRS).
Methods: We introduced the concept of the ratio of optical density (ROD) with and without CRO and combined it with matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) to establish a new protocol for the rapid detection of CRS.
Dissemination of Ceftriaxone-Resistant Enteritidis Harboring Plasmids Encoding or Gene in China.
Antibiotics (Basel)
May 2024
Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.
Enteritidis was the primary foodborne pathogen responsible for acute gastroenteritis. The growing ceftriaxone resistance poses a significant threat to public health. Infection with Enteritidis has emerged as a major public health concern, particularly in developing countries.
View Article and Find Full Text PDFTrends in typhoid fever during the COVID-19 pandemic in Pakistan.
J Infect Dev Ctries
April 2024
Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Article Synopsis
- Pakistan has been facing a significant outbreak of extensively drug-resistant (XDR) typhoid, and researchers investigated how the COVID-19 pandemic affected its spread from 2020 to 2022.
- During the early COVID-19 period, typhoid cases declined due to restrictions and improved hygiene, though resistance to antibiotics like ceftriaxone continued to rise, indicating persistent XDR typhoid.
- As pandemic restrictions eased in 2022, typhoid cases grew again, emphasizing the need for precise testing and vaccination to manage both diseases effectively.
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