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The smooth monostratified ganglion cell: evidence for spatial diversity in the Y-cell pathway to the lateral geniculate nucleus and superior colliculus in the macaque monkey. | LitMetric

AI Article Synopsis

  • The primate visual system features around 20 different pathways from retinal ganglion cells that project to the lateral geniculate nucleus (LGN) and superior colliculus, but the significance of this early diversity for visual processing is not fully understood.
  • Researchers identified a new type of ganglion cell, called smooth monostratified cells, which share properties with known parasol cells, such as high sensitivity to contrast and a specific receptive field structure.
  • Both cell types may originate from similar presynaptic circuitry, but they exhibit distinct characteristics, suggesting they contribute to different types of visual information processing within the primate visual system.

Article Abstract

In the primate visual system approximately 20 morphologically distinct pathways originate from retinal ganglion cells and project in parallel to the lateral geniculate nucleus (LGN) and/or the superior colliculus. Understanding of the properties of these pathways and the significance of such extreme early pathway diversity for later visual processing is limited. In a companion study we found that the magnocellular LGN-projecting parasol ganglion cells also projected to the superior colliculus and showed Y-cell receptive field structure supporting the hypothesis that the parasol cells are analogous to the well studied alpha-Y cell of the cat's retina. We here identify a novel ganglion cell class, the smooth monostratified cells, that share many properties with the parasol cells. Smooth cells were retrogradely stained from tracer injections made into either the LGN or superior colliculus and formed inner-ON and outer-OFF populations with narrowly monostratified dendritic trees that surprisingly appeared to perfectly costratify with the dendrites of parasol cells. Also like parasol cells, smooth cells summed input from L- and M-cones, lacked measurable S-cone input, showed high spike discharge rates, high contrast and temporal sensitivity, and a Y-cell type nonlinear spatial summation. Smooth cells were distinguished from parasol cells however by smaller cell body and axon diameters but approximately 2 times larger dendritic tree and receptive field diameters that formed a regular but lower density mosaic organization. We suggest that the smooth and parasol populations may sample a common presynaptic circuitry but give rise to distinct, parallel achromatic spatial channels in the primate retinogeniculate pathway.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778055PMC
http://dx.doi.org/10.1523/JNEUROSCI.2986-08.2008DOI Listing

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