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The efficacy and safety of submucosal tunneling endoscopic resection in treating large esophageal subepithelial lesions.
Surg Endosc
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China.
Background: Submucosal tunneling endoscopic resection (STER) is considered an effective, safe and minimally invasive treatment for esophageal subepithelial lesions (SELs) with maximal dilameter less than 3.0 cm, yet its efficacy for lesions over 3.0 cm remains unclear.
View Article and Find Full Text PDFThe Specialized Donor Care Facility Model Improves Operating Room Efficiency.
Ann Thorac Surg Short Rep
September 2024
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.
Background: Organ procurement organizations coordinate organ donation through 2 distinct models of care: the conventional model, in which donors are managed at hospitals where brain death occurs, and the specialized donor care facility (SDCF) model, where brain dead donors are transferred to a freestanding facility. The aim of this study is to compare operating room efficiency for procurements between the SDCF and conventional models of care.
Methods: We performed a prospective analysis of operating room efficiency between thoracic donor procurement operations performed at a SDCF and other organ procurement organizations using the conventional model of care.
Three-Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction.
Adv Healthc Mater
January 2025
Department of Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers a promising solution to the persistent challenges in colorectal cancer (CRC) treatment. In this study, a "three-level nanoparticle rocket" strategy is developed by engineering CuO, a multifunctional Cu-based nanoenzyme that is photothermal and has electron transfer properties and antioxidant efficiency. CuO effectively remodels the inflammatory environment by scavenging reactive oxygen species, thereby overcoming the traditional limitations of PTT.
View Article and Find Full Text PDFCognitive training related changes in fMRI activations: a neural mechanism of transfer to executive functions in normal aging.
Alzheimers Dement
December 2024
University of Texas at Dallas, Richardson, TX, USA
Background: Improvement of cognitive functions is often accompanied by changes in brain function after cognitive training in older adults. In this large‐scale dual‐site fMRI study we investigated the effects of BrainHQ cognitive training (CT; ®Posit Science Inc.) and an active control (AC) group on brain activations during a demanding executive control (EC) task among cognitively normal older adults.
View Article and Find Full Text PDFAlzheimer’s Disease Prediction and Implications for Insurance.
Alzheimers Dement
December 2024
Center for Life Ethics, University of Bonn, Bonn, Germany
Background: The possibilities to determine the individual risk of persons to develop future Alzheimer’s Disease and dementia have greatly increased in recent years. Promising and little invasive methods, e.g.
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