Introduction: A case of cefepime-induced nonconvulsive status epilepticus in a 15-year-old child with end stage renal disease on hemodialysis is reported. Clinical symptoms and EEG dramatically improved 48 h after discontinuation of cefepime.
Methods: Twenty-five cases of nonconvulsive status epilepticus associated with cefepime that have been reported in the literature are reviewed.
Results: The average age was 60 years [15-86], our patient is the second pediatric patient reported, and 56% of cases occurred in women. The cefepime dosage was adjusted to the renal function in 5 cases. All except 1 patient have impaired renal function (CRF: 17 cases, ARF: 7 cases). The symptoms start 1-15 days after starting cefepime, mean 6 days. The outcome was good after discontinuation of cefepime therapy and anticonvulsant treatment, but lethal outcome was also reported in 2 cases. One fatality was related to status epilepticus.
Conclusion: The clinicians' awareness must be increased about cefepime-induced nonconvulsive status epilepticus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12028-008-9166-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
When patients with Creutzfeldt-Jakob disease are misdiagnosed as having nonconvulsive status epilepticus.
Epilepsia
January 2025
Epilepsy Unit, Hôpital Gui de Chauliac, Montpellier, France.
Contemporary studies report nonconvulsive status epilepticus (NCSE) in Creutzfeldt-Jakob disease (CJD), based on benzodiazepine (BZP)-responsive epileptiform discharges on the electroencephalogram (EEG), with the following false syllogism: (1) intravenous (IV) administration of BZPs usually suppress ictal activity in NCSE; (2) in CJD, periodic sharp wave complexes (PSWCs) are suppressed by IV BZPs; (3) therefore, these patients have NCSE. This is a simplistic and invalid conclusion, because authors of 20th-century science reports have clearly shown that IV BZPs, short-acting barbiturates, and drugs with no antiseizure effects, such as chloral hydrate and IV naloxone, suppress PSWCs, but patients fall asleep with no clinical improvement. In contrast, IV methylphenidate transiently improves both the EEG and clinical states.
View Article and Find Full Text PDFReversible subcortical Dark White Matter lesions in nonconvulsive status epilepticus: a rare but clinically significant finding.
Acta Neurol Belg
December 2024
Lamezia Terme Hospital, Catanzaro, Italy.
[Absence status epilepticus in adults].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Burnasyan Federal Medical Biophysical Center, Moscow, Russia.
Absence status epilepticus (ASE) is a type of nonconvulsive status epilepticus, in which varying grade of consciousness impairment lasting more than 15 minutes and are accompanied by constant generalized spike-wave complexes with a frequency of 2.5-4 Hz on the electroencephalogram (EEG). ASE can be observed in various epileptic syndromes, usually detected in children.
View Article and Find Full Text PDF[Leading symptom: motor manifestations with impaired consciousnes : Management of epileptic seizures and status epilepticus].
Med Klin Intensivmed Notfmed
December 2024
Neurologische Klinik, Standort Gießen, Universitätsklinikum Gießen und Marburg, Klinikstraße 33, 35392, Gießen, Deutschland.
Epileptic seizures, which are often accompanied by a reduction in vigilance, are a common emergency. Every first-time epileptic seizure should be investigated further. Particular attention should be paid to whether it is an acute symptomatic seizure, which is an acute event characterized by a metabolic disorder or acute cerebral damage within a certain period of time, or possibly epilepsy.
View Article and Find Full Text PDFAccuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator: AccuRASE Study.
Neurology
January 2025
Neurology, Yale School of Medicine, New Haven, CT.
Background And Objectives: The use of rapid response EEG (rr-EEG) has recently expanded in limited-resource settings and as a supplement to conventional EEG to rapidly detect and treat nonconvulsive status epilepticus. The study objective was to test the accuracy of an rr-EEG's automated seizure burden estimator (ASBE).
Methods: This is a retrospective observational study using multiple blinded reviewers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!