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Mast cells: key players in digestive system tumors and their interactions with immune cells.
Cell Death Discov
January 2025
Department of Endoscopy and Digestive System, Guizhou Provincial People's Hospital, Guiyang, China.
Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health and in the pathophysiology of various illnesses, including allergies, cardiovascular diseases and autoimmune diseases. Recent studies in tumor-related research have demonstrated that mast cells exert a substantial influence on tumor cell behavior and the tumor microenvironment, exhibiting both pro- and anti-tumor effects.
View Article and Find Full Text PDFBackground Cardiorenal syndrome (CRS) refers to the bidirectional interactions between the acutely or chronically dysfunctioning heart and kidney that lead to poor outcomes. Due to the evolving literature on renal impairment and heart failure with preserved ejection fraction (HfpEF), this review aimed to highlight the pathophysiological pathways, diagnosis using imaging and biomarkers and management of CRS in patients with HFpEF. Further studies are needed to validate the use of novel biomarkers, especially for early diagnosis and prognostication.
View Article and Find Full Text PDFInhibition of human tumor cell migration by a rice-derived chimeric cysteine protease inhibitor.
An Acad Bras Cienc
December 2024
Universidade Federal do Rio Grande do Sul - UFRGS, Programa de Pós-Graduação em Biologia Celular e Molecular - PPGBCM, Centro de Biotecnologia, Av. Bento Gonçalves, 9500, Agronomia, 90650-001 Porto Alegre, RS, Brazil.
Article Synopsis
- The cystatin superfamily is vital for inhibiting cysteine proteases, which are involved in important biological functions like seed development and disease resistance in plants, and tumor progression in humans.
- A novel rice-derived chimeric legumain inhibitor was evaluated through simulations and laboratory tests, showing strong stability and affinity for the legumain enzyme.
- The study indicates that the chimeric Oryzacystatin I mutant could be a valuable candidate for developing new cancer treatments due to its effectiveness in reducing tumor cell migration and viability.
Minimizing Acute Kidney Injury in Pediatric Cardiac Surgery: Incidence, Early Detection, and Preemptive Measures.
Cureus
November 2024
Anaesthesiology, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University), Pune, IND.
Article Synopsis
- The study investigates the occurrence of acute kidney injury (AKI) in pediatric patients undergoing cardiac surgery, aiming to identify its incidence and possible risk factors while testing new early detection biomarkers.
- Conducted from October 2022 to June 2024, the study involved 44 children and assessed kidney function before and after surgery using various measurements, including serum creatinine and novel biomarkers like cystatin C and NGAL.
- AKI was found in 31.8% of patients, with a significant relationship between lower intraoperative hematocrit levels and higher AKI incidence, suggesting that maintaining optimal hematocrit and using low-dose vasopressin may help reduce AKI risk.
Purified α-Amylase from Bacillus cereus exhibits antibiofilm and antiquorum sensing activities against uropathogenic Escherichia coli, Downregulating fimH, and papC virulence genes: implications for urinary tract infections.
BMC Microbiol
November 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Background And Aim: Pathogenic Escherichia coli is a known harmful microorganism that takes advantage of favorable conditions to cause various infections in healthcare settings, such as bloodstream infections related to catheters, as well as infections in the urinary and respiratory tracts. E. coli utilizes biofilm development as a means to enhance its virulence and pathogenicity.
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