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Cost-effectiveness intervention thresholds for romosozumab and teriparatide in the treatment of osteoporosis in the UK.
Osteoporos Int
December 2024
Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Unlabelled: Sequential romosozumab-to-alendronate or sequential teriparatide-to-alendronate can be a cost-effective treatment option for postmenopausal women at very high risk of fracture.
Purpose: To estimate the 10-year probability of a major osteoporotic fracture (MOF) at which sequential treatment with romosozumab or teriparatide followed by alendronate, compared with alendronate alone, becomes cost-effective in a UK setting.
Methods: A microsimulation model with a Markov structure was used to simulate fractures, costs, and quality-adjusted life years (QALYs), in women receiving sequential treatment with either romosozumab or teriparatide followed by alendronate, compared with alendronate alone.
[Osteoporosis-Definition, risk assessment, diagnosis, prevention and treatment (update 2024) : Guidelines of the Austrian Society for Bone and Mineral Research].
Wien Klin Wochenschr
October 2024
Privatordination Prof. Dr. Astrid Fahrleitner-Pammer.
Background: Austria is among the countries with the highest incidence and prevalence of osteoporotic fractures worldwide. Guidelines for the prevention and management of osteoporosis were first published in 2010 under the auspices of the then Federation of Austrian Social Security Institutions and updated in 2017. The present comprehensively updated guidelines of the Austrian Society for Bone and Mineral Research are aimed at physicians of all specialties as well as decision makers and institutions in the Austrian healthcare system.
View Article and Find Full Text PDFPerformance of the Brazilian Fracture Assessment Risk Tool (FRAX) model and the age-dependent intervention thresholds according to National Osteoporosis Guideline Group (NOGG) guidelines on fracture prediction in community-dwelling older adults: the São Paulo Ageing and Health (SPAH) Study.
Arch Osteoporos
July 2024
Bone Metabolism Laboratory, Rheumatology Division, Faculdade de Medicina, Universidade de Sao Paulo, Disciplina de Reumatologia, Av. Dr. Arnaldo, 455, 3° Andar, Sala 3105, Sao Paulo, SP, 01246-903, Brazil.
Article Synopsis
- The SPAH study involved a cohort of elderly Brazilians at higher fracture risk and evaluated the effectiveness of the FRAX tool in predicting fractures, particularly without considering bone density.
- Over a follow-up period of approximately 4.3 years, the study found that fractures occurred in 22% of women and 15% of men, with FRAX showing better predictive ability for non-vertebral fractures and major osteoporotic fractures, especially in women.
- Overall, the findings suggest that while FRAX is a valuable tool for assessing fracture risk in this population, certain parameters, such as sex and bone density, can influence its predictive accuracy.
Development of an opportunistic diagnostic prediction algorithm for osteoporosis and fragility fracture risk estimates from forearm radiographs (The OFFER1 Study).
JBMR Plus
April 2024
Ibex Innovations Ltd., Sedgefield, TS21 3FD, United Kingdom.
Osteoporosis and associated fractures are an increasingly prevalent concern with an ageing population. This study reports testing of IBEX Bone Health (IBEX BH) software, applied following acquisition of forearm radiographs. IBEX Bone Health analyses the radiograph to measure areal bone mineral density (aBMD) at the examination site.
View Article and Find Full Text PDFDiagnosis and Management of Osteoporosis: A Comprehensive Review of Guidelines.
Obstet Gynecol Surv
November 2023
Assistant Professor, Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Importance: Osteoporosis causes increased morbidity and mortality, and thus poses a significant economic burden to the health systems worldwide.
Objective: The aim of this study was to review and compare the most recently published major guidelines on diagnosis and management of this common medical entity.
Evidence Acquisition: A thorough comparative review of the most influential guidelines from the RACGP (Royal Australian College of General Practitioners), the ESCEO-IOF (European Society for Clinical and Economic Aspects of Osteoporosis-International Osteoporosis Foundation), the NOGG (National Osteoporosis Guideline Group), the NAMS (North American Menopause Society), the ES (Endocrine Society), and the ACOG (American College of Obstetricians and Gynecologists) was conducted.
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