Objective: To analyze the incidence, clinical features and the predisposing factors of fungal septicemia, and investigate the risk factors for death due to fungal septicemia and the prognosis of the patients.

Methods: We retrospectively analyzed the clinical data of 91 patients with fungal septicemia diagnosed in the last 17 years, including 60 patients with clinical cure or improvement, and 31 who die of the disease. Based on the results by univariate analysis, the data were analyzed using logistic multiple regression and Fisher's discriminant analysis.

Results: Fungal septicemia had many predisposing factors with high mortality rate. Univariate analysis revealed significant differences between the cured/improved cases and the fatal cases for 12 variables, including advanced age, complication by bacterial infection, septic shock, multiple organ dysfunction syndrome (MODS), ICU patients, cortical hormone therapy, surgery, chemotherapy, use of immunopotentiating agents, length of hospital stay before antifungal therapy, time of anti-fungus therapy and types of invasive procedures. Logistic multiple regression analysis showed that the types of invasive procedures, MODS, surgery and prolonged hospital stay before antifungal therapy were the independent risk factors for fungal septicemia-related death. Fisher's linear discriminant equation was established for predicting the prognosis of the disease.

Conclusion: The types of invasive procedure, MODS, surgery and prolonged hospital stay before antifungal therapy are the independent risk factors for fungal septicemia-related death, and the patients' prognosis can be predicted using Fisher's linear discriminant equation.

Download full-text PDF

Source

Publication Analysis

Top Keywords

fungal septicemia
20
factors fungal
12
risk factors
12
hospital stay
12
stay antifungal
12
antifungal therapy
12
types invasive
12
factors death
8
death fungal
8
predisposing factors
8

Similar Publications

Blood Culture Contamination and Diagnostic Stewardship: From a Clinical Laboratory Quality Monitor to a National Patient Safety Measure.

J Appl Lab Med

January 2025

Centers for Disease Control and Prevention (CDC), Office of Laboratory Systems and Response (OLSR), Divsion of Laboratory Systems (DLS), Atlanta, GA, United States.

Laboratory analysis of blood cultures is vital to the accurate and timely diagnosis of bloodstream infections. However, the reliability of the test depends on clinical compliance with standard operating procedures that limit the risk of inconclusive or incorrect results. False-negative blood culture results due to inadequate volumes of blood can result in misdiagnosis, delay therapy, and increase patients' risk of developing or dying from bloodstream infections.

View Article and Find Full Text PDF

This study aims to explore the pathogenic potential of as a rare pathogen in immunocompetent individuals and to analyze how mental health status may influence susceptibility to infection. We report a case of bacteremia in a 31-year-old immunocompetent female who developed infection during an episode of severe depression. Although the patient exhibited self-harm tendencies, a thorough physical examination did not reveal any external wounds or signs of injury.

View Article and Find Full Text PDF

A Narrative Review of Invasive Candidiasis in the Intensive Care Unit.

Ther Adv Pulm Crit Care Med

December 2024

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization, (MICRO), St James' Hospital, Dublin, Ireland.

species is the most common cause of invasive fungal infection in the critically ill population admitted to the intensive care unit (ICU). Numerous risk factors for developing invasive candidiasis (IC) have been identified, and some, like the breach of protective barriers, abound within the ICU. Given that IC carries a significant mortality, morbidity, and healthcare cost burden, early diagnosis and treatment have become an essential topic of discussion.

View Article and Find Full Text PDF
Article Synopsis
  • Bloodstream infections need quick bacterial identification for effective treatment, with traditional methods being slow.
  • The study compared direct identification using MALDI-TOF MS with the post-culture method, finding that while direct identification had a lower success rate (64.8%), it provided results in under an hour.
  • Despite its limitations, the direct method could significantly enhance diagnosis speed, making it a potentially valuable tool in conjunction with established methods.
View Article and Find Full Text PDF

This study aimed to analyze the homology between carbapenem-resistant organisms (CRO) intestinal colonization strains and bloodstream infection (BSI) strains in patients undergoing hematopoietic stem cell transplantation (HSCT), confirming the clinical use of the real-time rectal swab Xpert Carba-R assay, and investigate its feasibility in early warning of BSI. Drug-resistant strains obtained from rectal swabs and blood culture samples of patients undergoing the same HSCT from January 2021 to December 2021 were collected and analyzed. The homology of the CRO intestinal colonization and BSI strains was confirmed using strain identification, antimicrobial resistance phenotyping, whole genome sequencing (WGS), multilocus sequence typing (MLST), and carbapenemase type identification.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!