AI Article Synopsis
- The management of hemodialysis patients involves regulating calcium, phosphorus, and parathyroid hormone to prevent complications related to bone and soft tissues.
- Recent interest has emerged around the positive effects of active vitamin D on patient outcomes, though its use can lead to elevated calcium and phosphorus levels.
- Cinacalcet hydrochloride has been proposed as a new treatment option that lowers parathyroid hormone levels and helps balance serum calcium and phosphorus, and when used with vitamin D, it enhances the effectiveness of treatment for chronic kidney disease-mineral bone disorder in hemodialysis patients.
Article Abstract
The management of hemodialysis patients with chronic kidney disease-mineral bone disorder includes treatment to control levels of calcium, phosphorus and parathyroid hormone, so as to prevent bone and soft-tissue complications. Recently, pleiotropic effects of active vitamin D have attracted much attention, and its effect on outcome has also gained recognition. However, administration of active vitamin D may cause hypercalcemia and hyperphosphatemia. Now, the use of a novel class of drugs, cinacalcet hydrochloride, has been proposed as a strategy to reduce parathyroid hormone secretion, while decreasing levels of serum calcium, phosphorus, and calcium x phosphorus products. Among subjects with secondary hyperparathyroidism undergoing hemodialysis, combined therapy with cinacalcet and vitamin D sterols improved achievement of the biochemical targets for chronic kidney disease-mineral bone disorder recommended by the guidelines.
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| http://dx.doi.org/10.1111/j.1744-9987.2008.00628.x | DOI Listing |
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