AI Article Synopsis
- The study focused on analyzing genetic variations of the rabies virus phosphoprotein in China, particularly in high-incidence areas like Guangxi, Guizhou, and Hunan.
- The nucleotide and amino acid sequences of the P gene were sequenced, showing a high similarity ranging from 82.1% to 100% for nucleotides and 87.5% to 100% for amino acids, indicating that minor variations don't significantly affect the protein’s biological functions.
- All examined rabies viruses are classified under genotype 1, suggesting they have a shared evolutionary history, with some isolates from Hunan possibly related to those found in Thailand.
Article Abstract
Objective: Characterization of rabies virus phosphoprotein through analyzation of genetic variations about rabies virus phosphoproteins in high-incidence regions in China.
Methods: The nucleotide sequence of the P gene of Guangxi, Guizhou and Hunan provinces positive sample's were sequenced, and the P region's similarity and phylogenetic analyses were completed by using softer wares.
Results: The similarity of P region's nucleotide sequence is 82.1%-100%, while, the similarity of amino acid sequence is 87.5%-100%. A little variation in phosphoprotein cannot influence its biological functions.
Conclusion: All rabies viruses isolated from Guangxi, Guizhou and Hunan provinces belong to genotype 1 and share same phylogenesis and same genome characteristic; Virus distribution presents unique Characterization; Some virus isolates from Hunan province and Thailand may come from the same virus.
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