This study investigated performance on the Delis-Kaplan Executive Function System (D-KEFS) Tower Test in a sample of 12 patients with focal lesions in the lateral prefrontal cortex (PFC) and 12 control participants. PFC patients performed worse overall, spent more time on each move, and committed significantly more rule violations. The rule violation measure demonstrated 83% sensitivity and 100% specificity in the detection of lesions. Findings highlight the importance of error monitoring in the assessment of executive functioning. These preliminary results suggest that the lateral PFC may be critical for self-monitoring/inhibition and speed of processing in planning tasks.
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http://dx.doi.org/10.1080/13803390802448669 | DOI Listing |
Brain Sci
August 2024
Laboratory of Neurodegenerative Diseases, Center of Interdisciplinary Research and Innovation (CIRI-AUTH), Balcan Center, Buildings A & B, 57001 Thessaloniki, Greece.
This study aimed to examine the associations between specific sleep parameters and specific aspects of cognitive functioning in individuals diagnosed with mild cognitive impairment (MCI), compared with healthy controls (HCs) by using cognitive, subjective, and objective sleep measures. A total of 179 participants were enrolled, all aged ≥ 65 years (mean age = 70.23; SD = 4.
View Article and Find Full Text PDFCortex
December 2023
Shirley Ryan AbilityLab, Chicago, USA; Northwestern University Medical School, Cognitive Neurology and Psychiatry and Behavioral Sciences and Physical Medicine and Rehabilitation, Chicago, IL, USA.
The prefrontal cortex (PFC) is associated with many cognitive functions, including planning. In the neuropsychology literature planning is reduced to "look ahead" ability and most extensively studied with the "tower" tasks. The most influential theoretical explanation is that planning is required in the absence of a routine solution and PFC patients have difficulty coping with novelty.
View Article and Find Full Text PDFFront Neurol
July 2023
Sleep Education and Research Laboratory, UCL Institute of Education, London, United Kingdom.
Study Objectives: Compared to typically developing children and young adults (CYA-TD), those living with Sickle Cell Disease (CYA-SCD) experience more cognitive difficulties, particularly with executive function. Few studies have examined the relative importance of silent cerebral infarction (SCI), haemoglobin and arterial oxygen content on age-related cognitive changes using cross-sectional or longitudinal (developmental trajectory) data. This study presents cohort data from a single timepoint to inform studies with multiple timepoints.
View Article and Find Full Text PDFAppl Neuropsychol Adult
September 2024
Department of Neurosurgery, Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Almost all of our everyday activities depend on executive function (EF) skills. In line with the increasing attention to the ecological validation of neuropsychological assessment and intervention methods, this study aimed to explore the ecological validity of a relevant set of widely used EF tests, mostly from well-known paradigms of EF assessment, in predicting driving ability. Ninety-six healthy novice drivers ( = 26.
View Article and Find Full Text PDFNeurotoxicology
September 2022
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Background: Problem-solving skills build upon three core executive functions: inhibition, working memory, and cognitive flexibility. There is evidence of adverse associations of prenatal exposure to manganese (Mn) with core executive functions, but less is known about Mn associations with problem-solving or potential mediators of this association.
Objectives: This study aimed to investigate the association of prenatal Mn exposure with problem-solving and to identify potential neuropsychological mechanisms through which this association may be mediated.
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