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[A retrospective analysis of the clinical characteristics of 63 patients with vestibular neuritis].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
To retrospectively analyze the results of auditory examination,vestibular function examination and laboratory examination of 63 patients diagnosed as vestibular neuritis.Methods:A total of 63 patients diagnosed with vestibular neuritis hospitalized in the Department of Otolaryngology, Head and Neck Surgery of the Third Affiliated Hospital of Sun Yat-sen University, from October 2012 to December 2022 were recruited. All patients met the diagnostic criteria for the 2022 Bárány association vestibular neuritis.
View Article and Find Full Text PDFPressure Myography.
Methods Mol Biol
December 2024
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vasomotor function (constriction, dilation) can be assessed ex vivo using the pressure myograph technique, also referred to as perfusion myography in older literature. The technique involves isolating an artery (or any other blood vessel/lymphatic vessel) from an animal research model or from surgery-resected human tissue. The vessel preparation is mounted between two tiny glass pipettes through which a physiological saline solution (usually Krebs') is perfused while superfusing the preparation with the same solution.
View Article and Find Full Text PDFSex-specific mechanisms of cerebral microvascular BK dysfunction in a mouse model of Alzheimer's disease.
Alzheimers Dement
December 2024
Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona, USA.
Introduction: Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca-activated K channels (BK) regulate cerebrovascular reactivity and are impaired in AD. BK activity depends on intracellular Ca (Ca sparks) and nitro-oxidative post-translational modifications.
View Article and Find Full Text PDFQuantification of leptomeningeal collateral blood flow in hypertensive rats during ischemic stroke.
J Stroke Cerebrovasc Dis
December 2024
School of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, Australia; Heart and Stroke Program, Hunter Medical Research Institute, Newcastle, Australia. Electronic address:
Objectives: There is increasing evidence that poor leptomeningeal collateral blood flow in hypertensive animals is due to increased vascular myogenic tone, indicating that therapies to enhance collateral blood flow during ischemic stroke may be particularly effective. To develop such therapies, we need a greater understanding of the factors that regulate collateral blood flow in the setting of hypertension. Therefore, we aimed to quantify blood flow velocity, diameter and absolute blood flow in individual collateral vessels in an ischemic stroke model in spontaneously hypertensive rats (SHRs) and determine which factors had the greatest influence on blood flow.
View Article and Find Full Text PDFRad-mediated inhibition of Ca1.2 channel activity contributes to uterine artery haemodynamic adaptation to pregnancy.
J Physiol
December 2024
Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, USA.
The striking increase of uterine blood flow during pregnancy is essential for normal fetal development as well as for cardiovascular well-being of the mother. Yet, the underlying mechanisms of pregnancy-mediated vasodilatation of the uterine artery are not fully understood. In this study, we test the hypothesis that Rad, a monomeric G protein, is a novel regulatory mechanism in inhibiting Ca1.
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