Breast cancer after treatment of Hodgkin's lymphoma: general review.

Int J Radiat Oncol Biol Phys

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Published: December 2008

AI Article Synopsis

  • Improved survival rates in Hodgkin's lymphoma patients have led to a higher occurrence of second cancers, particularly breast cancer in female survivors.
  • This review highlights the risks associated with breast cancer following radiation treatment, along with suggested long-term surveillance strategies and the best timing for screening.
  • The article also addresses the unique challenges in managing breast cancer in these patients due to previous radiation therapy, discussing characteristics of late-onset breast cancer and potential treatment options.

Article Abstract

The improved survival rates among patients with Hodgkin's lymphoma over the past few decades have come with increased incidence of second malignancies. One of the major concerns among female survivors is the significantly elevated risk of breast cancer that appears with extended follow-up. In this review, we include the published literature regarding the risk of breast cancer after irradiation for Hodgkin's lymphoma. We also present the possible long-term surveillance strategies and the optimal time to start screening these women. This could potentially help in early detection of secondary breast cancers and consequently improve outcomes. Furthermore, because of prior radiotherapy, the management of the breast cancer among this unique population has been controversial. We discuss the characteristics of breast cancer that occurs after Hodgkin's lymphoma and also treatment options that could be implemented.

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http://dx.doi.org/10.1016/j.ijrobp.2008.07.060DOI Listing

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