Objective: To observe immunoreaction to PVA/n-HA+ PA66 biological composite material after being implanted into animal body.
Methods: PVA/n-HA+PA66 composite materials were implanted into mouse subcutaneous tissue. Histologial examination was performed at 2, 4, 6 weeks, the amount of CD3, CD4+, CD8+ in blood and IL-1, IL-6, TNF-alpha in spleen cells was measured at the same time.
Results: The amount of CD3, CD4+, CD8+ in mouse blood and IL-1, IL-6, TNF-alpha in mouse spleen cells were not different with the control groups at 2, 4, 6 weeks (P > 0.05). The fibrous tissue and some blood vessels were found growing into the porous materials, which resulted in composite materials intergration of proliferative structure. The reject reaction was not found.
Conclusion: PVA/n-HA+PA66 biological composite material does not cause immune rejection after being implanted into animal body, verifying its good biocompatibility.
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