AI Article Synopsis
- Ciprofloxacin and levofloxacin, commonly prescribed fluoroquinolone antibiotics, have been linked to dysglycemia and central nervous system complications.
- The study reveals that these antibiotics negatively affect glucose transport in HepG2 cells by inhibiting the glucose transporter type 1 (GLUT1).
- Exposure to high concentrations of ciprofloxacin or levofloxacin significantly reduces GLUT1 function and glucose uptake, suggesting that these disruptions may contribute to the adverse effects observed with these drugs.
Article Abstract
Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibition is associated with inhibited glucose transporter type 1 (GLUT1) function. When exposed to ciprofloxacin or levofloxacin at maximum plasma concentrations (C(max)) and 5x of C(max) concentrations, GLUT1 mRNA expression, cell surface GLUT1 protein expression and glucose uptake were significantly reduced. These findings imply that disturbed cellular glucose transport and GLUT1 function may underlie the dysglycemic and CNS effects of ciprofloxacin and levofloxacin.
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| http://dx.doi.org/10.1016/j.toxlet.2008.10.017 | DOI Listing |
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