AI Article Synopsis

  • Nitric oxide acts as a messenger in the brain and is linked to various issues like depression and anxiety; studies suggest that blocking nitric oxide synthase (NOSI) may have antidepressant effects.
  • This study focuses on the effects of a specific NOS inhibitor (TRIM) and compares it to a traditional antidepressant (fluoxetine) in mice under mild stress for 35 days.
  • Findings show that both TRIM and fluoxetine improved stressed mice's coat condition, grooming behavior, and reduced aggression, suggesting that NOS inhibitors could be a new type of antidepressant targeting neuronal NOS.

Article Abstract

Nitric oxide is an intracellular messenger which is involved in several functions and pathologies such as depression, anxiety, learning and memory. In many studies nitric oxide synthase inhibitors (NOSI) were shown to possess antidepressant-like effects in animal models of depression. The aim of this study is to investigate the effects of a selective neuronal and inducible nitric oxide synthase inhibitor TRIM (30 mg/kg/day, 35 days) in mice subjected to unpredictable chronic mild stress and then compare it's effect with a conventional selective serotonin reuptake inhibitor fluoxetine (15 mg/kg/day, 35 days). Stressed vehicle animals showed a significant disturbed coat state when compared with nonstressed animals and this effect was reversed by TRIM or fluoxetine. Both TRIM and fluoxetine prevented the stress-induced deficit in the grooming behaviour in the splash test. TRIM and fluoxetine also significantly decreased the attack frequency when compared to the stressed control group in the resident-intruder test. These results support the assumption that NOS inhibitors can be a new class of antidepressant drugs possibly acting on neuronal NOS.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbb.2008.10.013DOI Listing

Publication Analysis

Top Keywords

nitric oxide
12
trim fluoxetine
12
neuronal inducible
8
unpredictable chronic
8
chronic mild
8
mild stress
8
oxide synthase
8
mg/kg/day days
8
trim
5
effects neuronal
4

Similar Publications

Background: Current treatments for penile erectile structures reconstruction are limited and remain a great challenge in clinical practice. Tissue engineering techniques using different seed cells and scaffolds to construct a neo-tissue open promising avenues for penile erectile structures repair and replacement and show great promise in the restoration of: structure, mechanical property, and function which matches the original tissue.

Methods: A comprehensive literature review was conducted by accessing the NCBI PubMed, Cochrane, and Google Scholar databases from January 1, 1990, to January, 1, 2022 using the search terms "Tissue engineering, Corpus cavernosum (CC), Tunica albuginea (TA), Acellular Matrix, Penile Reconstruction".

View Article and Find Full Text PDF

Manganese (Mn), a trace element, has been documented to exert an important role in the metabolism of cholesterol. Cholesterol gallstone (CG) pathogenesis is directly linked to biliary cholesterol imbalance which could be due to diabetes complications or mismanagement. NF-κβ pathway, an inflammatory regulator, has been implicated in metabolic disease especially in the context of diabetes and gallstone formation.

View Article and Find Full Text PDF

Diabetes can affect male fertility via oxidative stress and endocrine system disruption. Nanomedicine based on natural products is employed to address diabetes complications. The current study aims to investigate the potential beneficial effect of propolis extract nanoparticles against diabetes-induced testicular damage in male rats.

View Article and Find Full Text PDF

Norcrohalane A, an Unusual C15 nor-Halimane-Type Diterpenoid from Croton crassifolius.

Chem Biodivers

December 2024

Jinan University, college of Pharmacy, 601, the west of Huangpu street, Not Available, 510632, Guangzhou, CHINA.

An unusual C15nor-halimane-type diterpenoid, norcrohalane A (1), a new nor-lasserane-type sesquiterpenoid, norcrolasane A (2), along with four known compounds (3-6) were isolated from the roots of Croton crassifolius. Compound 1 represents the first example of a C15nor-halimane-type diterpenoid, which features a rare 6/6/6 tricyclic ring system, and the A ring is aromatic. Compound 2 is a rare nor-lasserane-type sesquiterpenoid.

View Article and Find Full Text PDF

Impact of Hormone on Growth and GA Regulation of Anthocyanin Biosynthesis in Suspension-Culture Cells of Cyclocarya paliurus.

Biotechnol Bioeng

December 2024

Jiangxi Key Laboratory of Natural Products and Functional Foods, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, China.

Hormones are effective in regulating plant metabolism and, therefore, are often used in plant cell culture to increase the yield of target products. This study investigated the effects of hormones on the growth and anthocyanin biosynthesis of suspension-cultured red Cyclocarya paliurus cells. Additionally, the mechanism by which gibberellin induces anthocyanin biosynthesis was explored through multi-omics integrated analysis and the assay of the dynamic changes in signaling molecule concentration.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: