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Immune thrombocytopenia (ITP) is an autoimmune disorder marked by a low platelet count, leading to symptoms ranging from mild to severe bleeding. It can be triggered by various factors, including idiopathic origins, medications, malignancies, infections, and other autoimmune conditions. Though rare, ITP can also occur postvaccination.
View Article and Find Full Text PDFComparison of HEmorrhage on CT versus MRI After ThrombEctomy: The HECATE study.
Stroke Vasc Interv Neurol
November 2024
NIH/NINDS, Stroke Branch, Bethesda, MD, USA.
Background: The characterization of hemorrhage following acute stroke intervention has largely been CT-based. We sought to compare MRI- and CT-based scoring of hemorrhage after acute endovascular therapy (EVT) applying the Heidelberg Bleeding Classification (HBC) to assess inter-modal agreement and quantify inter-rater agreement.
Methods: Consecutive acute stroke patients were included in this retrospective study if they: i) had MRI and CT ≤12 hours of each other OR ii) had CT bracketed by MRI pre- and post-CT [i.
The Subtle Signs of Scurvy: A Paediatric Case Misleading Clinicians.
Cureus
November 2024
General Paediatrics, Worcestershire Acute Hospitals NHS Trust, Worcestershire, GBR.
Scurvy, arising from vitamin C deficiency, remains relevant despite historical declines. Scurvy commonly presents with severe leg pain, reluctance to walk, and limping. Other symptoms include gingival bleeding, hypertrophy, and ecchymoses.
View Article and Find Full Text PDFRecurrent Immune Thrombocytopenia After Liver Transplantation in a Pediatric Patient: Successful Bridging Treatment With Eltrombopag Before Partial Splenic Embolization and Review of the Literature.
Exp Clin Transplant
October 2024
From the Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
Although thrombocytopenia is a frequent complication that develops after liver transplantation, immune thrombocytopenia rarely occurs post-transplant. We present an 8-year-old boy who experienced 2 immune thrombocytopenia episodes that occurred 72 and 93 months after liver transplant while the patient was on tacrolimus therapy. The patient, who had primary diagnosis being deoxyguanosine kinase deficiency, received a liver transplant from his father at 1 year of age.
View Article and Find Full Text PDFArticle Synopsis
- A study evaluated the safety and efficacy of endovascular thrombectomy in patients with acute large-vessel occlusion and tandem lesions, focusing on those with low (0-5) and high (6-10) Alberta Stroke Program Early Computed Tomography Scores (ASPECTS).
- The analysis included 691 patients, revealing that those with low ASPECTS had significantly lower odds of achieving a favorable functional outcome (mRS 0-2) and higher odds of suffering symptomatic intracranial hemorrhage compared to those with high ASPECTS.
- The researchers concluded that endovascular thrombectomy may lead to poorer functional recovery in patients with tandem lesions and low ASPECTS, particularly in the
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