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MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway.
Cell Death Dis
January 2025
Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
The involvement of B lymphocytes in the pathogenesis of rheumatoid arthritis (RA) is well-established, with their early and aberrant activation being a crucial factor. However, the mechanisms underlying this abnormal activation in RA remain incompletely understood. In this study, we identified a significant reduction in MAPK4 expression in both RA patients and collagen-induced arthritis (CIA) mouse models, which correlates with disrupted B cell activation.
View Article and Find Full Text PDFPerennial Grasses on Stony Sandy Loam : Summary of Results of Long-Term Experiment in Northern Europe Region (1995-2024).
Plants (Basel)
January 2025
Voke Branch, Lithuanian Research Centre for Agriculture and Forestry, Zalioji 2, LT-02232 Vilnius, Lithuania.
Grasses can sustain soil functions despite nutrient depletion, which can have serious consequences for soil processes and ecosystem services. This paper summarizes the results of the long-term experiment (1995-2024) carried out in within a temperate climate zone, focusing on the productivity of natural and managed grasslands; their succession changes over time, and so do the effects on soil chemical properties, and soil organic carbon (SOC) sequestration. The results indicated that two land uses-abandoned land (AL) and grassland fertilized with mineral fertilizers (MGf)-can be effectively applied to prevent soil degradation.
View Article and Find Full Text PDFEx Vivo Propagation of Pinctada Birnavirus Using Mantle Tissue Fragment Culture: Application for Measuring Replication at Different Temperatures, TCID Assay, and UV Sensitivity.
Pathogens
January 2025
Japan Fisheries Research and Education Agency, Pathology Division, Aquaculture Research Department, Fisheries Technology Institute, Minami-Ise 516-0193, Mie, Japan.
Pinctada birnavirus (PiBV) is the causative agent of summer atrophy in pearl oyster ( (Gould)). The disease, which induces mass mortality in juveniles less than 1 year old and abnormalities in adults, was first reported in Japan in 2019. Research on the disease has been hindered by the lack of cell lines capable of propagating PiBV.
View Article and Find Full Text PDFGenotype x environment interaction effect on grain yield of cowpea (Vigna unguiculata (L.) Walp) in Deciduous forest and Sudan savanna ecologies of Ghana.
PLoS One
January 2025
Department of Botany, University of Ghana, Legon, Ghana.
Cowpea is deemed as a food security crop due to its ability to produce significant yields under conditions where other staples fail. Its resilience in harsh environments; such as drought, heat and marginal soils; along with its nitrogen-fixing capabilities and suitability as livestock feed make cowpea a preferred choice in many farming systems across sub-Saharan Africa (SSA). Despite its importance, Cowpea yields in farmers' fields remain suboptimal, primarily due to biotic and abiotic factors and the use of either unimproved varieties or improved varieties that are not well-suited to local conditions.
View Article and Find Full Text PDFEvaluation of Local Tumor Outcomes Following Microwave Ablation of Colorectal Liver Metastases Using CT Imaging: A Comparison of Visual versus Quantitative Methods.
Radiol Imaging Cancer
January 2025
From the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, England (J.D.S., L.K., L.P., J.M., N.K., D.M.K., E.J.); Institute of Cancer Research, London, England (N.P., D.M.K.); and Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, the Netherlands (W.O.).
Purpose To compare visual versus quantitative ablation confirmation for identifying local tumor progression and residual tumor following microwave ablation (MWA) of colorectal liver metastases (CRLM). Materials and Methods This retrospective study included patients undergoing MWA of CRLM from October 2014 to February 2018. Two independent readers visually assessed pre- and postprocedure images and semiquantitatively scored for incomplete ablation, using a six-point Likert scale, and extracted quantitative imaging metrics of minimal ablative margin (MAM) and percentage of tumor outside of the ablation zone, using both rigid and deformable registration.
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