The objective of this study is to develop a validated, patient-oriented questionnaire to assess urgency and associated life impact. We interviewed six urogynecologists and urologists and five patients with overactive bladder (OAB) symptoms about urinary urgency. Based on this data, we composed the first draft of our Urgency Severity and Impact Questionnaire (USIQ). A focus group of OAB patients provided feedback on the USIQ draft. The revised questionnaire has two parts: symptom severity (USIQ-S) and related quality of life (USIQ-QOL). The questionnaire was given to patients with clinically diagnosed OAB to establish face, content and discriminatory validity. Cronbach's alpha for the USIQ-S and USIQ-QOL were 0.85 and 0.90, respectively. USIQ-QOL was moderately correlated with UDI-6 (r = 0.49, p < 0.001), IIQ-7 (r = 0.77, p < 0.001), and OAB-q (r = 0.73, p < 0.001). Mean USIQ-QOL and USIQ-S scores differed by clinical diagnosis. The USIQ is an easily understood questionnaire with adequate validity for use in clinical practice and research.
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http://dx.doi.org/10.1007/s00192-008-0770-0 | DOI Listing |
Children (Basel)
December 2024
Nephrology Unit, Paediatric Specialties Division, Geneva University Hospitals (HUG), 1205 Geneva, Switzerland.
Urinary tract dilations (UTDs) are the most frequent prenatal renal anomaly. The spectrum of etiologies causing UTD ranges from mild spontaneously resolving obstruction to severe upper and lower urinary tract obstruction or reflux. The early recognition and management of these anomalies allows for improved renal endowment prenatally and ultimately better outcome for the child.
View Article and Find Full Text PDFEnviron Health Insights
January 2025
Department of Theology and Religious Education, College of Liberal Arts, De La Salle University, Manila, Philippines.
I read with great interest the recent study by Omohwovo on wastewater management challenges in Africa, which has strong parallels with the Philippines' own struggles in this area. Like Africa, our country is experiencing rapid population growth and urbanization without the necessary infrastructure to support effective wastewater treatment. The Philippines is also facing poor wastewater management that has led to severe heath concerns for humans, animals, and ecosystem.
View Article and Find Full Text PDFSci Rep
January 2025
State Key Laboratory of Geohazard Prevention and GeoEnvironment Protection, Chengdu University of Technology, Chengdu, 610059, Sichuan, China.
Pakistan's geographic location makes it an important land hub between Central Asia, Middle East-North Africa, and China. However, the railways, roads, farmland, riverways, and residential quarters in the Piedmont plains of Baluchistan province in northwestern Pakistan are under serious threat of flooding in the summer of 2022. The urgency and severity of climate change's impact on humanity are underscored by the significant threats posed to human life and property in Piedmont Plains environments through extreme flood events, which has garnered widespread concerns.
View Article and Find Full Text PDFDrug Dev Res
February 2025
Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy.
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a neurodegenerative pathology caused by accumulation of mutant neuroserpin (NS) polymers inside the endoplasmic reticulum (ER) of neurons, leading to cellular toxicity and neuronal death. To date, there is no cure for FENIB, and only palliative care is available for FENIB patients, underlining the urgency to develop therapeutic strategies. The purpose of this work was to create a cellular system designed for testing small molecules able to reduce the formation of NS polymers.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
December 2024
Nivel, Netherlands Institute for Health Services Research, Otterstraat 118, Utrecht, 3513 CR, The Netherlands.
Background: At the beginning of the COVID-19 pandemic in 2020, little was known about the spread of COVID-19 in Dutch nursing homes while older people were particularly at risk of severe symptoms. Therefore, attempts were made to develop a nationwide COVID-19 repository based on routinely recorded data in the electronic health records (EHRs) of nursing home residents. This study aims to describe the facilitators and barriers encountered during the development of the repository and the lessons learned regarding the reuse of EHR data for surveillance and research purposes.
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