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| http://dx.doi.org/10.1128/AAC.00736-08 | DOI Listing |
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Genomic characterization of ST11-KL25 hypervirulent KPC-2-producing multidrug-resistant from China.
iScience
December 2024
Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China.
The global prevalence of ST11 hypervirulent carbapenem-resistant (hv-CRKP) isolates has been increasingly documented, yet genomic characterization of this clone remains insufficiently explored. Here, we report a clinical ST11-KL25 hv-CRKP strain (KP156) that exhibited resistance to multiple antibiotics and demonstrated hypervirulence in a mouse infection model. Whole-genome sequencing revealed that KP156 harbored one virulence plasmid (pKP156-Vir) and two resistance plasmids (pKP156-KPC and pKP156-tetA).
View Article and Find Full Text PDFEmergent Escherichia coli of the highly virulent B2-ST1193 clone producing KPC-2 carbapenemase in ready-to-eat vegetable.
J Glob Antimicrob Resist
December 2024
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil. Electronic address:
Objectives: Critical priority carbapenem-resistant pathogens constitute a worldwide public health problem. Escherichia coli ST1193 is an emerging high-risk clone that demonstrates prolonged gut persistence, and association with community-onset urinary and bloodstream infections. The purpose of this study is to report microbiological and genomic data on the emergence of KPC-2-producing E.
View Article and Find Full Text PDFGenetic characteristics of clinical carbapenem-resistant Klebsiella pneumoniae: epidemic ST11 KPC-2-producing strains and non-negligible NDM-5-producing strains with diverse STs.
Sci Rep
October 2024
The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Klebsiella pneumoniae is among the most important Gram-negative pathogens that can cause serious nosocomial infections. The emergence and prevalence of hypervirulent carbapenem-resistant K. pneumoniae (Hv-CRKP) pose a significant challenge to public health.
View Article and Find Full Text PDFEmergence and transmission of the high-risk ST78 clone of OXA-48-producing in a single hospital in Taiwan.
Emerg Microbes Infect
December 2024
Department of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Article Synopsis
- * Over 80% of the identified CPEH strains belong to the high-risk ST78 lineage, which carries a specific plasmid (pOXA48-CREH) related to another endemic plasmid found in a different lineage (ST11).
- * The research indicates that the ST78 lineage has rapidly spread and acquired various plasmids that facilitate carbapenem resistance, emphasizing the need for ongoing genomic monitoring and strategic measures to contain this threat in hospitals.
Investigation of the Rapid Emergence of Colistin Resistance in a Newborn Infected with KPC-2-Producing Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae.
J Glob Antimicrob Resist
September 2024
Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Article Synopsis
- - The study investigates a severe infection caused by hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKp) in a premature infant, emphasizing its colistin resistance and how this resistance evolved while inside the patient.
- - Three strains of KPC-producing CRKp were isolated from a patient undergoing colistin therapy, and their susceptibility to various antibiotics was tested to understand their resistance profiles better.
- - Whole-genome sequencing revealed that all strains belonged to the ST11 clone, carried certain virulence and resistance genes, and demonstrated that colistin resistance was due to a significant deletion affecting the mgrB gene.
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