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| http://dx.doi.org/10.1093/scan/nsn031 | DOI Listing |
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Investigating the Spatio-Temporal Signatures of Language Control-Related Brain Synchronization Processes.
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Université libre de Bruxelles (ULB), UNI - ULB Neuroscience Institute, Laboratoire de Neuroanatomie et Neuroimagerie translationnelles (LN2T), Brussels, Belgium.
Language control processes allow for the flexible manipulation and access to context-appropriate verbal representations. Functional magnetic resonance imaging (fMRI) studies have localized the brain regions involved in language control processes usually by comparing high vs. low lexical-semantic control conditions during verbal tasks.
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January 2025
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Precision, or personalized, medicine aims to stratify patients based on variable pathogenic signatures to optimize the effectiveness of disease prevention and treatment. This approach is favorable in the context of brain disorders, which are often heterogeneous in their pathophysiological features, patterns of disease progression and treatment response, resulting in limited therapeutic standard-of-care. Here we highlight the transformative role that human induced pluripotent stem cell (hiPSC)-derived neural models are poised to play in advancing precision medicine for brain disorders, particularly emerging innovations that improve the relevance of hiPSC models to human physiology.
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Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
For over a century after their discovery astrocytes were regarded merely as cells located among other brain cells to hold and give support to neurons. Astrocytes activation, "astrocytosis" or A1 functional state, was considered a detrimental mechanism against neuronal survival. Recently, the scientific view on astrocytes has changed.
View Article and Find Full Text PDFProspective Harmonization, Common Data Elements, and Sharing Strategies for Multicenter Pre-Clinical Traumatic Brain Injury Research in the Translational Outcomes Project in Neurotrauma Consortium.
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Division of Neuroscience, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Effective team science requires procedural harmonization for rigor and reproducibility. Multicenter studies across experimental modalities (domains) can help accelerate translation. The Translational Outcomes Project in NeuroTrauma (TOP-NT) is a pre-clinical traumatic brain injury (TBI) consortium charged with establishing and validating noninvasive TBI assessment tools through team science.
View Article and Find Full Text PDFAge-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions.
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Toxicology Unit, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
The aging process is marked by a time-dependent deterioration in cellular functions, particularly the immune and neural systems. Understanding the phenotype acquisition of microglia, the sentinel immune cells of the brain, is crucial for understanding the nature of age-related neurological diseases. However, the specific phenotype adopted by microglia during aging remains a subject of debate and is contingent on the chosen experimental model.
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