AI Article Synopsis
- The study aimed to assess the levels of VEGF, Cox-2, and aromatase in the endometrial tissue of women with myomas and related conditions.
- Hysteroscopy was performed on 118 women, with evaluations showing that certain conditions like adenomyosis and endometriosis were prevalent in a portion of these patients.
- The findings suggest that natural progesterone and combined oral contraceptives significantly reduce the expression of VEGF, aromatase, and Cox-2 in the endometrium during the menstrual cycle.
Article Abstract
Background: The study was conducted to evaluate vascular endothelial growth factor (VEGF), Cox-2 and aromatase expression in the endometrium of uteri with myomas and other associated pathologies.
Study Design: Hysteroscopy was performed in 118 women of reproductive age with myomas and menorrhagia, 40 of whom were using a pill containing 75 mcg gestodene+30 mcg ethinylestradiol. Aromatase p450, VEGF and Cox-2 expression was detected using immunohistochemistry. Fisher's Exact Test and the Mann-Whitney test were used in the statistical analysis, with significance established at p<.05.
Results: In patients with myomas and menorrhagia, associated pathologies such as adenomyosis, endometrial polyps and endometriosis were found in 32%, 12% and 17% of cases, respectively. Aromatase, Cox-2 and VEGF expression was greater during the proliferative phase compared to the luteal phase of the cycle or following oral contraceptive use.
Conclusion: Endogenous progesterone or combined oral contraceptives are potent inhibitors of VEGF, aromatase and Cox-2 expression in the endometrium of patients with myomas and menorrhagia.
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| http://dx.doi.org/10.1016/j.contraception.2008.07.002 | DOI Listing |
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