Objectives: Decrease acute pain after breast cancer surgery by an infiltration of ropivacaine. Analyse effect on chronic pain.
Study Design: Prospective randomised double blind versus placebo study.
Patients And Methods: Eighty-one patients randomised between two groups received wound infiltration with 40 ml of ropivacaine 4.75 mg/ml or placebo. Acute pain was assessed during 24h with analogical visual scale and antalgic consumption. One year later, telephonic interviews looked for chronic pain and evaluate it with McGill Pain Questionnaire.
Results: Analogical visual scale pain score, antalgic consumption and chronic pain incidence were similar between groups.
Conclusion: Ropivacaine scar infiltration provided no acute or chronic pain relief after breast cancer surgery.
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http://dx.doi.org/10.1016/j.annfar.2008.10.006 | DOI Listing |
Cureus
January 2025
Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, USA.
Obesity is a complex and non-communicable disease with a pandemic entity. Currently, multiple causes can lead to obesity, and it is not always easy to create a direct relationship between physical inactivity, poor quality of nutrients consumed, and calculation of excess calories. Among the associated comorbidities, obesity creates a dysfunctional environment of respiratory rhythms at the central and peripheral levels, with functional, morphological, and phenotypic alteration of the diaphragm muscle.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Background: Chronic low back pain is a major cause of pain and disability with limited effective therapies. Metformin is a safe, inexpensive, well-tolerated drug that has pleotropic effects, including effects on pain pathways that may influence low back pain. The aim of this randomised, double-blind, placebo-controlled trial is to determine whether metformin reduces low back pain over 4 months in individuals with chronic low back pain.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Objective: Osteoarthritis is a chronic, debilitating disease that causes long-term pain and immobility. Germline deletion of Phlpp1 or administration of small molecules that inhibit Phlpp1 prevents post-traumatic osteoarthritis (PTOA) in mice. However, the chondrocyte-intrinsic role of Phlpp1 in PTOA progression is unknown.
View Article and Find Full Text PDFIntroduction: To correlate the direct and indirect morphological uterus sonographic assessment (MUSA) features of adenomyosis with clinical symptoms severity.
Material And Methods: This observational prospective study was conducted at a tertiary care institute from April 2023 to March 2024, involving 254 women aged 18 to 45 years with a regular menstrual cycle and ultrasound-confirmed diagnosis of adenomyosis. Detailed clinicodemographic data were collected, including symptoms such as painful menses, heavy menstrual bleeding (HMB), chronic pelvic pain (CPP), and bowel/bladder symptoms.
Heliyon
January 2025
Wolfson Sensory, Pain and Regeneration Centre, King's College London, London, United Kingdom.
Neuropathic pain following peripheral nerve injury results from maladaptive changes in neurons and immune cells contribution to mechanisms underlying chronic pain. Specifically, in dorsal root ganglia (DRG), sensory neuron cell bodies release extracellular vesicles (EVs) which promote pro-inflammatory macrophage accumulation that facilitates nociceptive signalling. Here, we show that macrophages shuttle EVs to neurons.
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