Background: The Neuropsychiatric Inventory (NPI) is commonly used in dementia trials to quantify and qualitate changes in psychiatric symptoms.
Methods: A questionnaire was administered to clinical trial raters to assess whether they were being trained to administer and score the NPI differently between clinical trial protocols.
Results: Responses to the survey indicated that there are differences between clinical trials protocols in how the instrument is administered and scored.
Discussion: Clarification of administration and scoring rules are provided, including the behavioral sampling period, whether premorbid characteristics are considered, and what behaviors are considered in rating frequency, severity, and caregiver distress.
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| http://dx.doi.org/10.1016/j.jalz.2008.09.002 | DOI Listing |
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