Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.

J Theor Biol

IMB UMR CNRS 5251-ESTBB, Université de Bordeaux 2, 146 rue Léo-Saignat, F 33076 Bordeaux-Cedex, France.

Published: June 2009

Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.

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http://dx.doi.org/10.1016/j.jtbi.2008.09.037DOI Listing

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