Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.
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http://dx.doi.org/10.1016/j.jtbi.2008.09.037 | DOI Listing |
Ecol Lett
January 2025
Center for Reservoir and Aquatic System Research, Baylor University, Waco, Texas, USA.
Diazotrophic cyanobacteria can overcome nitrogen (N)-limitation by fixing atmospheric N; however, this increases their energetic, iron, molybdenum, and boron costs. It is unknown how current and historic N-supplies affect cyanobacterial elemental physiology beyond increasing demands for elements involved in N-fixation. Here, we examined the changes in pigment concentrations, N-storage, and the ionome (i.
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December 2024
College of Physical Science and Technology, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
Nanomaterial-biomembrane interactions constitute a critical biological process in assessing the toxicity of such materials in theoretical studies. However, many investigations simplify these interactions by using membrane models containing only one or a few lipid types, deviating significantly from the complexity of real membrane compositions. In particular, cholesterol, a ubiquitous lipid essential for regulating membrane fluidity and closely linked to various diseases, is often overlooked.
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December 2024
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Cardiac sex-difference functional studies have centred on measurements of twitch force and Ca dynamics. The energy expenditures from these two cellular processes: activation (Ca handling) and contraction (cross-bridge cycling), have not been assessed, and compared, between sexes. Whole-heart studies measuring oxygen consumption do not directly measure the energy expenditure of these activation-contraction processes.
View Article and Find Full Text PDFMetabolites
November 2024
Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, Polytechnique Montréal, Centre-Ville Station, P.O. Box 6079, Montréal, QC H3C 3A7, Canada.
: This study explores the generation of singlet oxygen (SO) through methylene blue (MB) activation as a metabolic intervention for ovarian cancer. We aimed to examine the role of SO in modulating mitochondrial function, cellular metabolism, and proliferation in ovarian cancer cell lines compared to control cells. : The study utilized two ovarian cancer cell lines, OV1369-R2 and TOV1369, along with ARPE-19 control cells.
View Article and Find Full Text PDFProtein Sci
January 2025
Department of Physical Chemistry, Institute of Biotechnology, and Unit of Excellence in Chemistry Applied to Biomedicine and Environment, School of Sciences, University of Granada, Granada, Spain.
The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.
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