Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1157/13127282 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metformin Toxicity Leading to Severe Refractory Hyperkalemia and Metabolic Acidosis: A Case Report.
Cureus
June 2024
Internal Medicine, Ascension Saint Agnes Hospital, Baltimore, USA.
Metformin is a widely prescribed, oral, anti-diabetic agent for the treatment of type 2 diabetes mellitus (DM2). While generally well-tolerated, metformin can accumulate in patients with acute kidney injury (AKI) or chronic kidney disease (CKD), leading to potentially life-threatening complications such as metformin-associated lactic acidosis (MALA). Severe hyperkalemia is a rare but serious manifestation of metformin toxicity.
View Article and Find Full Text PDFEuglycemic Ketoacidosis and Lactic Acidosis Associated With Metformin Toxicity.
Cureus
May 2024
Department of Internal Medicine, University of Central Florida Hospital Corporation of America (HCA) Healthcare Graduate Medical Education (GME), Orlando, USA.
In patients with diabetes, diabetic ketoacidosis (DKA) is a well-documented potential complication, usually presenting with hyperglycemia, anion gap acidosis, and positive ketones. Metformin toxicity in the setting of acute renal failure is also a well-known cause of lactic acidosis. However, metformin-induced euglycemic ketoacidosis is less well-known or studied.
View Article and Find Full Text PDFMetformin toxicity in the intensive care unit: A case series and review of the literature.
Int J Crit Illn Inj Sci
March 2024
Department of Pulmonary and Critical Care Medicine, St. Luke's University Health Network, Bethlehem, PA, USA.
Metformin toxicity is a life-threatening condition with high morbidity and mortality. Toxicity predominantly occurs in the setting of acute renal dysfunction, as the drug is solely eliminated by the kidneys. While this risk is widely known to clinicians, diagnosing metformin toxicity is challenging because commercially available serum metformin levels require days to weeks to result.
View Article and Find Full Text PDFMethylene Blue in Metformin Intoxication: Not Just Rescue But Also Initial Treatment.
Pediatr Emerg Care
November 2024
From the Departmant of Intensive Care Medicine, Mersin City Training and Research Center, Mersini Turkey.
Metformin (MTF) is a widely used oral antidiabetic medication. Regardless the reason, high doses of MTF cause lactic acidosis as a result of its effects on mitochondrial ATP production and no-mediated vascular smooth muscle relaxation. Metformin-associated lactic acidosis can be life-threatening despite all treatments.
View Article and Find Full Text PDFHigh risk and low prevalence diseases: Metformin toxicities.
Am J Emerg Med
October 2023
Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, TX, USA. Electronic address:
Introduction: Metformin toxicity is a rare but serious condition that carries with it a high rate of morbidity and mortality.
Objective: This review highlights the pearls and pitfalls of metformin toxicity, including diagnosis, initial resuscitation, and management in the emergency department (ED) based on current evidence.
Discussion: Metformin is a common medication used for treatment of diabetes mellitus.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!