Primary alcohols can be coupled with secondary benzylic alcohols by an air-stable catalytic system involving terpyridine ruthenium or iridium complexes.
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http://dx.doi.org/10.1039/b815547j | DOI Listing |
ACS Catal
January 2025
Fakultät für Chemie und Pharmazie, Universität Regensburg, Regensburg 93040, Germany.
Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand design and base selection, achieving effective synergy between these components remains challenging. We present here a general approach to nickel-catalyzed photoredox reactions employing -butylamine as a cost-effective bifunctional additive, acting as the base and ligand.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SE-10691, Sweden.
Herein, we present a highly efficient allylic substitution of carbonates with Grignard reagents using a reusable cellulose-supported nanocopper catalyst. This approach highlights the first instance of heterogeneous catalysis for the cross-coupling of allylic alcohol substrates with Grignard reagents. The method features high yields, excellent regioselectivity, and complete chirality transfer.
View Article and Find Full Text PDFBMC Chem
January 2025
The Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, 341000, Jiangxi, People's Republic of China.
J Org Chem
January 2025
International Joint Research Center for Molecular Science, College of Chemistry and Environmental Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.
We disclosed a new strategy for the synthesis of 1,2-amino alcohols enabled by visible light without the requirement of a photocatalyst and metal. Under light irradiation at 400 nm, the reaction of carbonyl derivatives and -arylamines proceeds via an electron-donor-acceptor (EDA) intermediate, obtaining diverse vicinal amino alcohols decorated with a two-electron-rich/-deficient aryl group.
View Article and Find Full Text PDFSmall
December 2024
LSRE-LCM - Laboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials, Faculty of Engineering, University of Porto, Rua Dr Roberto Frias, Porto, 4200-465, Portugal.
The oxidative cross-coupling of benzyl alcohol (BA) and benzylamine (BZA) is employed for the production of the corresponding imine, N-benzylidenebenzylamine (BZI), under visible light irradiation (light-emitting diodes (LE with λ = 417 nm) and mild reaction conditions. The cesium bismuth halide perovskites (CsBiBr, CBB) are synthesized by a one-step solution process as a sustainable alternative for the widely used Pb-halide perovskites. The CBB photocatalyst is immobilized on a polyethylene terephthalate (PET) structure designed explicitly for three-dimensional (3D) printing to operate in both batch and continuous modes to overcome the need for a final catalyst separation step.
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