AI Article Synopsis
- The study focuses on developing optimized methods to create photoswitchable molecular structures using stilbene and thioaurone chromophores.
- It explores how varying the length of linkers between these chromophores and peptide strands affects the flexibility and photochromic behavior of dipeptidomimetics.
- Stronger conformational directing properties are observed in more rigid thioaurone structures compared to more flexible stilbene derivatives, supported by both theoretical computations and NMR spectroscopy analyses.
Article Abstract
Optimized synthetic strategies for the preparation of photoswitchable molecular scaffolds based on stilbene or on thioaurone chromophores and their conformationally directing properties, as studied by computations and by NMR spectroscopy, are addressed. For the stilbene peptidomimetics 1, 2 and 3, the length of connecting linkers between the chromophore and the peptide strands was varied, resulting in photochromic dipeptidomimetics with various flexibility. Building blocks of higher rigidity, based on para-substituted thioaurone (4 and 6) and meta-substituted thioaurone chromophores (5 and 7) are shown to have a stronger conformationally directing effect. Design, synthesis, theoretical and experimental conformational analyses are presented.
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| http://dx.doi.org/10.1039/b812001c | DOI Listing |
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Article Synopsis
- The study focuses on developing optimized methods to create photoswitchable molecular structures using stilbene and thioaurone chromophores.
- It explores how varying the length of linkers between these chromophores and peptide strands affects the flexibility and photochromic behavior of dipeptidomimetics.
- Stronger conformational directing properties are observed in more rigid thioaurone structures compared to more flexible stilbene derivatives, supported by both theoretical computations and NMR spectroscopy analyses.
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