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Current and Emerging Therapies for Lysosomal Storage Disorders.
Drugs
January 2025
Lysosomal Storage Disorders Unit, Royal Free London NHS Foundation Trust, University College London, London, NW3 2QG, UK.
Lysosomal storage disorders (LSDs) are rare inherited metabolic disorders characterized by defects in the function of specific enzymes responsible for breaking down substrates within cellular organelles (lysosomes) essential for the processing of macromolecules. Undigested substrate accumulates within lysosomes, leading to cellular dysfunction, tissue damage, and clinical manifestations. Clinical features vary depending on the degree and type of enzyme deficiency, the type and extent of substrate accumulated, and the tissues affected.
View Article and Find Full Text PDFAt the intersection of literature and psychoanalysis, this essay draws on Freud's discovery of the infantile sexual unconscious to explore moments in the late novels of Henry James, in which an adult protagonist both recognizes and disavows the visible evidence of a sexual relationship. The essay considers Hans Holbein's 1533 painting, The Ambassadors, as a possible source for Henry James' choice of title for his 1903 novel: the painting's visual play with point of view touches on the narrative disavowal of what is there to be seen. The essay explores some narrative dimensions of Freud's writing to highlight the dynamic disclosure of the infantile within the adult.
View Article and Find Full Text PDFThe use of traditional and complementary medicine by cancer patients in SSA: A scoping review.
Health SA
December 2024
Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Background: The rate of traditional and complementary medicine (T&CM) use is increasing worldwide, including among cancer patients who are often willing to try alternate therapies. Despite T&CM popularity in sub-Saharan Africa (SSA), there are limited data on its use with conventional treatments.
Aim: This scoping review aims to describe the prevalence of use, reasons for use, most common types of T&CM used, patient satisfaction with T&CM and disclosure of T&CM use to physicians among cancer patients in SSA.
Large-scale and long-term wildlife research and monitoring using camera traps: a continental synthesis.
Biol Rev Camb Philos Soc
January 2025
Wildlife Observatory of Australia (WildObs), Queensland Cyber Infrastructure Foundation (QCIF), Brisbane, Queensland, 4072, Australia.
Camera traps are widely used in wildlife research and monitoring, so it is imperative to understand their strengths, limitations, and potential for increasing impact. We investigated a decade of use of wildlife cameras (2012-2022) with a case study on Australian terrestrial vertebrates using a multifaceted approach. We (i) synthesised information from a literature review; (ii) conducted an online questionnaire of 132 professionals; (iii) hosted an in-person workshop of 28 leading experts representing academia, non-governmental organisations (NGOs), and government; and (iv) mapped camera trap usage based on all sources.
View Article and Find Full Text PDFAn Interview with Rita Charon.
J Med Humanit
January 2025
McGovern Medical School, 6431 Fannin Street, Houston, TX, 77030, USA.
This is an edited transcript of an interview with Rita Charon. Nathan Carlin conducted the interview in her apartment in New York City on October 18, 2024. They discussed a number of topics, including Charon's educational journey, her mentors, the founding of narrative medicine, the status of narrative medicine today as well as its future, the relationship between narrative medicine and literature and medicine, and the ethics of writing about patients.
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