A simple continuous flow wet-spinning method to achieve mechanical reinforcement of the two oppositely charged biopolymers chitosan and gellan gum is described. The mechanical properties of these biopolymers are influenced by the order of addition. Using a facile method for mechanical reinforcement of gellan gum/chitosan fibers resulted in increases in Young's modulus, tensile strength, and toughness. Spinning gellan gum into chitosan resulted in the strongest fibers. We show that our fibers can provide a mechanical alternative for bio-fibers without the need of cross-linking. It is demonstrated that the fibers become ionically conducting in the presence of water vapor.
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http://dx.doi.org/10.1002/mabi.200800257 | DOI Listing |
Int J Biol Macromol
January 2025
MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea; Advanced Medical Device Research Center for Cardiovascular Disease, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea; Center for Next-Generation Sensor Research and Development, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea. Electronic address:
Critical-sized bone defects in osteosarcoma treatment demand multifunctional scaffolds that must effectively integrate two key functions, promoting osteogenesis and delivering targeted chemoprevention. This study introduces a dual-component system featuring pH-responsive hydrogels and hydroxyapatite-based fiber-reinforced biomimetic scaffolds designed for controlled and localized curcumin delivery, while addressing its solubility and stability issues. The hydrogel system comprises a double network of polyacrylic acid, sodium alginate, carboxymethyl cellulose, and potato starch, specifically modified to encapsulate curcumin.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Introduction: This study utilized a injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC) for addressing defects caused by bone cancer, and evaluated its promoting bone regeneration and exerting cytotoxic effects on osteosarcoma cells.
Methods: The material's physicochemical properties, biocompatibility with osteoblasts, and cytotoxicity toward osteosarcoma cells were rigorously analyzed.
Results: The findings demonstrate that CPSC-Cur signicantly prolongs the setting time, which can be optimized by adding silanized cellulose nanober (CNF-SH) to achieve a balance between workability and mechanical strength.
J Prosthodont
January 2025
The Office of Assistant Dean for Research, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
Purpose: This study aimed to evaluate and compare the fracture resistance of long-span fixed provisional restorations fabricated using milling, three-dimensional (3D) printing, and conventional methods.
Materials And Methods: Sixty specimens were prepared, divided into four groups of 15 each, corresponding to four fabrication methods: computer-aided design and computer-aided manufacturing (CAD-CAM) milled provisional resins, 3D-printed provisional resins, 3D-printed permanent resins, and conventional bis-acryl restorations reinforced with wire. The specimens underwent a three-point bending test using a universal testing machine to measure fracture resistance, quantified as maximum force (in Newtons).
Sci Rep
January 2025
Department of Mechanical and Industrial Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India.
Fiber-reinforced polymer composites are subjected to harsh environmental conditions over the course of their designed lifespan. Studying the aging process of fiber-reinforced polymer composites exposed to boiling water is critical for improving their durability. This study uses a hand lay-up technique to fabricate composites from glass fiber, bamboo fiber, nanoclay, and epoxy.
View Article and Find Full Text PDFBiofabrication
January 2025
Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, 123 St Stephen's Green, Dublin, DO2 YN77, IRELAND.
Osteomyelitis, a severe bone infection, is an extremely challenging complication in the repair of traumatic bone defects. Furthermore, the use of long-term high-dose antibiotics in standard treatment increases the risks of antibiotic resistance. Herein, an antibiotic-free, collagen silver-doped hydroxyapatite (coll-AgHA) scaffold reinforced with a 3D printed polycaprolactone (PCL) framework was developed with enhanced mechanical properties to be used in the repair of load-bearing defects with antimicrobial properties as a preventative measure against osteomyelitis.
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