Two clones of mouse-human hybridomas, secreting human monoclonal antibodies to a peanut allergen Ara h1, were generated from human peripheral blood lymphocytes transformed with Epstein--Barr virus, followed by cell fusion with mouse myeloma cells. Epitope analysis with overlapping peptides synthesized on a multi-pin apparatus revealed antibody-binding sequences of Ara h1 protein.
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http://dx.doi.org/10.1007/s10616-005-1578-0 | DOI Listing |
J Alzheimers Dis
May 2023
Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Background: Clearance of tau seeds by immunization with tau antibodies is currently evaluated as therapeutic strategy to block the spreading of tau pathology in Alzheimer's disease and other tauopathies. Preclinical evaluation of passive immunotherapy is performed in different cellular culture systems and in wild-type and human tau transgenic mouse models. Depending on the preclinical model used, tau seeds or induced aggregates can either be of mouse, human or mixed origin.
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October 2022
Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
EBioMedicine
February 2022
AXON Neuroscience R&D Services SE; Bratislava, 811 02, Slovakia; Institute of Neuroimmunology, Slovak Academy of Sciences; Bratislava, 845 10, Slovakia.
Background: The emergence of new SARS-CoV-2 variants of concern B.1.1.
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January 2020
Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
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