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Potential neural progenitor cells in fetal liver and regenerating liver. | LitMetric

AI Article Synopsis

Article Abstract

From unfractionated embryonic mice liver cells, appreciable amount of spherical bodies containing nestin-positive cells were generated in the presence of neuronal growth factors. Following cultivation on poly-D: -lysine/laminin-coated slips, approximately 70% of the cells expressed neuronal markers, and 16% had long processes. Functional analysis of these long-process-bearing cells with the whole-cell patch clamp method showed an inward current in response to glutamate, GABA, and serotonin as the neuronal characteristics. Furthermore, regenerating liver in adult mice also contained nestin-positive cells to the same extent as fetal liver. Regenerating liver could have potential as a source of neural cells for autologous transplantation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553634PMC
http://dx.doi.org/10.1007/s10616-008-9150-3DOI Listing

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