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In the highly acclaimed 1991 play , which explores AIDS in the United States in the 1980s, one of the characters muses about the nature of knowledge and novelty: "Imagination can't create anything new, can it? It only recycles bits and pieces from the world and reassembles them into visions." Although the scene's intent is to ponder the limits of human experience and how the constraints of day-to-day reality are inescapable, the description of imagination aptly describes the creative shuffling that can lead to breakthroughs, like the ones recognized by at this time every year. In naming the drug lenacapavir as the 2024 Breakthrough of the Year, acknowledges the next, but by no means final, step in the drive to fight HIV/AIDS, where the rigors of the laboratory and the needs of humanity are inseparable.
View Article and Find Full Text PDFA real-world study of persistence and adherence to prescription medications in patients with chronic idiopathic constipation in the United States.
J Manag Care Spec Pharm
October 2024
Atrium Health Wake Forest Medical University, Charlotte, NC.
Background: At present, 4 prescription therapies have been approved by the US Food and Drug Administration for the treatment of chronic idiopathic constipation (CIC) in adults.
Objectives: To compare persistence with and adherence to prucalopride vs 3 other prescription medications for CIC in a US population.
Methods: This retrospective, observational cohort study used data from the IBM MarketScan Commercial Claims and Encounters and Medicare Supplemental Databases (January 2015-June 2020).
Patient out-of-pocket costs for guideline-recommended treatments for erectile dysfunction: a medicare cost modeling analysis.
Int J Impot Res
January 2025
Department of Urology, UC San Diego Health, San Diego, CA, USA.
Patient out-of-pocket (OOP) cost represents an access barrier to erectile dysfunction (ED) treatment. We determined OOP cost for men with ED covered by Fee-for-Service Medicare. Coverage policies were obtained from the Medicare Coverage Database for treatments recommended by the 2018 American Urological Association (AUA) guidelines.
View Article and Find Full Text PDFDaniel Callahan died on July 16, 2019, just short of his 89th birthday. In the years since, we have seen the overturning of abortion rights, a concern central to his scholarship and musings about the place of religion in American civic life. Callahan's journey from lay Catholic journalist and commentator at Commonweal to a co-founder of the Hastings Center, during his decade of doubt, is especially relevant today as America revisits established precedent governing a woman's right to choose.
View Article and Find Full Text PDFCharles Scriver: Epitome of the physician scientist.
Mol Genet Metab
December 2022
Division of Genetics and Genomics, Boston Children's Hospital, Department of Pediatrics Harvard Medical School, Boston, MA, USA. Electronic address:
Charles Scriver is a towering figure in the medical genetics community. At 92 he can look back upon a remarkable career that established the field of biochemical genetics, a subsection of medical genetics that is translating the developments in basic genetics into the diagnoses and treatments of inherited biochemical diseases. This biographical sketch summarizes the key achievements of Dr.
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