There are few practical methods available for evaluating training loads (TL) during swimming. The purpose of this study was to examine the ecological validity of the session-rating of perceived exertion (RPE) method for quantifying internal TL in competitive swimmers using heart rate (HR)-based methods and distance as criterion measures. This study also examined the correspondence between athlete and coach perceptions of internal TL using the session-RPE method. Twelve (six male, six female) well-trained swimmers (mean +/- SD: age 22.3 +/- 3.1 years, weight 71.8 +/- 11.6 kg, height 175.0 +/- 9.0 cm) participated in this study. All subjects completed a swimming step test to evaluate individual HR zones and blood lactate profile before undertaking 20 swim training sessions where RPE, HR, and distance covered were recorded. Training load was then calculated for each session using the session-RPE, HR-based methods, and session distance. The session-RPE scores were correlated to HR-based methods for measuring internal TL as well as training distance for each swimmer. All individual correlations between session-RPE, HR-based methods (r = 0.55-0.94; p < 0.05), and distance measures (r = 0.37-0.81; p < 0.05) were significant. Two-way ANOVA showed that there was a significant interaction for training intensity x coach-athlete perception, indicating that coach RPE was lower than athlete RPE for low-intensity sessions and higher than athlete RPE at high-intensity sessions. The results of this study suggest that session-RPE may provide a practical, noninvasive method for quantifying internal TL in competitive swimmers.
Homologous recombination (HR) is the principal pathway undertaken by a cell for the error-free repair of DNA double-strand breaks that are frequently encountered by the cell. HR can be initiated at the sites of DNA double-strand breaks by generating long stretches of single-stranded 3' DNA overhang through a process called DNA end resection. In one DNA end resection pathway, this is achieved via the concerted effort of specialized machinery involving the RecQ family helicase BLM, the helicase/endonuclease DNA2, and a single-strand DNA binding protein complex RPA.
Heart failure events in cardiovascular trials are often evaluated through centralized review, but its impact on treatment effect accuracy (in terms of hazard ratios) is uncertain.
In a study of seven trials, positive adjudication rates for heart failure events were generally lower than for cardiovascular deaths, affecting subsequent mortality risk.
Overall, while central adjudication showed some correlation between event types, it didn’t significantly change the results, suggesting that the need for centralized review should be tailored to each trial's objectives.
is an important fungus in food and industrial enzyme production. In , targeted knock-in transformation is primarily limited to homologous recombination (HR)-based systems, in which non-homologous end-joining (NHEJ)-disruptant hosts are required. However, preparation of hosts and transformation templates for such systems is laborious, in addition to other disadvantages.
Background: Heart rate is crucial for patients with septic shock, but there are few studies on the scope of heart rate. Therefore, we studied the relationship between different heart rates and mortality of critically ill patients with septic shock, and explored the optimal heart rate range, in order to provide new insights for clinical treatment of septic shock.
Methods: This retrospective study utilized time-series heart rate data from the Medical Information Mart for Intensive Care (MIMIC) IV database.
Accurate health risk prediction (HRP) is an effective means of reducing the hazards of heavy metal (HM) exposure. It can address the drawbacks of lag and passivity faced by health risk assessment. This study innovatively proposed an HRP method, MEL-HR, based on multilevel ensemble learning (MEL) technology and environment compatibility.
