The minichromosome maintenance (MCM) complex is thought to function as the replicative helicase in archaea and eukarya. The structure of the single MCM protein homologue from the archaeon Methanothermobacter thermautotrophicus is not yet clear, and hexameric, heptameric, octameric, and dodecameric structures, open rings, and filamentous structures have been reported. Using a combination of biochemical and structural analysis, it is shown here that the M. thermautotrophicus MCM helicase is active as a hexamer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1074/jbc.M806803200 | DOI Listing |
Publication Analysis
Top Keywords
methanothermobacter thermautotrophicus
8
thermautotrophicus mcm
8
mcm helicase
8
helicase active
8
mcm
4
active hexameric
4
hexameric ring
4
ring minichromosome
4
minichromosome maintenance
4
maintenance mcm
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!