AI Article Synopsis
- Curcumin, derived from turmeric, is studied for its effects on stress-related behaviors and brain chemistry in rats.
- Daily administration of curcumin reversed negative behavioral and biochemical changes caused by chronic stress, improving mood-related symptoms.
- When combined with piperine, curcumin's effects on neurotransmitters and depression-related outcomes were enhanced, suggesting a potential therapeutic strategy for treating depression.
Article Abstract
Curcumin, a yellow pigment extracted from rhizomes of the plant Curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout Asia. The present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. Curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase immobility period), biochemical (increase monoamine oxidase activity) and neurochemical (depletion of brain monoamine levels) alterations. The combination of piperine (2.5 mg/kg, i.p., 21 days), a bioavailability enhancer, with curcumin (20 and 40 mg/kg, i.p., 21 days) showed significant potentiation of its anti-immobility, neurotransmitter enhancing (serotonin and dopamine) and monoamine oxidase inhibitory (MAO-A) effects as compared to curcumin effect per se. This study provided a scientific rationale for the use of curcumin and its co-administration with piperine in the treatment of depressive disorders.
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| http://dx.doi.org/10.1016/j.pbb.2008.10.007 | DOI Listing |
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