Background: Exposure to ultraviolet (UV) radiation induces generation of reactive oxygen species, production of proinflammatory cytokines and melanocyte-stimulating hormone (MSH) as well as increase in tyrosinase activity. The potential photoprotective effects of Coccoloba uvifera extract (CUE) were evaluated in UV-stimulated melanocytes.
Methods: Human epidermal melanocytes were used as an in vitro model to evaluate the effects of CUE on the production interleukin-1alpha (IL-1alpha), tumor necrosis factor alpha (TNF-alpha), and alpha-MSH under basal and UV-stimulated conditions. Antioxidant and anti-tyrosinase activities were also evaluated in membrane lipid peroxidation and mushroom tyrosinase assay, respectively.
Results: Coccoloba uvifera L. showed antioxidant and anti-tyrosinase activities and also inhibited the production of IL-1alpha, TNF-alpha and alpha-MSH in melanocytes subjected to UV radiation (P<0.01). Moreover, CUE inhibited the activity of tyrosine kinase in cell culture under basal and UV radiation conditions (P<0.001), corroborating the findings of the mushroom tyrosinase assay.
Conclusion: This study supports the photoprotective potential of CUE.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0781.2008.00382.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In thermotolerance tests of tropical tree leaves, the chlorophyll fluorescence parameter F/F measured soon after heat exposure is not a reliable predictor of tissue necrosis.
Plant Biol (Stuttg)
January 2025
Smithsonian Tropical Research Institute, Panama City, Republic of Panama.
Tropical rainforests are hot and may be particularly sensitive to ongoing anthropogenic global warming. This has led to increased interest in the thermotolerance of tropical trees. Thermotolerance of leaves of two tropical tree species, Terminalia catappa and Coccoloba uvifera, was determined by exposing leaf samples to 15-min heat treatments, followed by measurements of potential photosystem II quantum yield (dark-adapted value of variable/maximum chlorophyll a fluorescence, F/F) after 24 h and 14 days, and visible damage (necrosis) after 14 days.
View Article and Find Full Text PDFCoccoloba uvifera L. associated with Scleroderma Bermudense Coker: a pantropical ectomycorrhizal symbiosis used in restoring of degraded coastal sand dunes.
Mycorrhiza
November 2024
Biotechnology Unit, Kanchi Mamunivar Government Institute for Postgraduate Studies and Research, Puducherry, India.
Coccoloba uvifera L. (Polygonacaeae), named also seagrape, is an ectomycorrhizal (ECM) Caribbean beach tree, introduced pantropically for stabilizing coastal soils and producing edible fruits. This review covers the pantropical distribution and micropropagation of seagrape as well as genetic diversity, functional traits and use of ECM symbioses in response to salinity, both in its native regions and areas where it has been introduced.
View Article and Find Full Text PDFMexican Coccoloba uvifera L. Leaf and Fruit Extracts: Identification of Pentacyclic Triterpenes and Volatile Profile by GC-MS.
Plant Foods Hum Nutr
September 2024
Laboratorio Integral de Investigación en Alimentos, Tecnológico Nacional de México, Instituto Tecnológico de Tepic, Tepic, Nayarit, México.
Mexican Coccoloba uvifera fruit contains polyphenols, flavonoids, and anthocyanins, while in the leaves, lupeol, α- and β-amyrin have been previously identified by HPLC. However, the low resolution by HPLC of pentacyclic triterpenes (PTs) is a limitation. Moreover, the volatile profile of C.
View Article and Find Full Text PDFCorrection to " leaves: Polyphenolic profile, Cytotoxicity, and Antioxidant Evaluation".
ACS Omega
November 2023
Chemistry of Tanning Materials and Leather Technology Department, Chemical Industries Research Institute, National Research Centre, 33 El-Bohouth Street (Former El-Tahrir Street), Dokki, Cairo 12622, Egypt.
[This corrects the article DOI: 10.1021/acsomega.3c04025.
View Article and Find Full Text PDFLeaves: Polyphenolic Profile, Cytotoxicity, and Antioxidant Evaluation.
ACS Omega
September 2023
Chemistry of Tanning Materials and Leather Technology Department, Chemical Industries Research Institute, National Research Centre, 33 El-Bohouth Street (Former El-Tahrir Street), Dokki, Cairo 12622, Egypt.
This study aimed to investigate the chemical composition of leaves and evaluate the antioxidant and antitumor effects of the total extract and its major metabolites. Four assays were used to determine the antioxidant activity, including radical scavenging abilities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), radical cation, and ferric-reducing power. Additionally, vincristine was used as a reference medication to examine the anticancer activity on Ehrlich aesthete carcinoma cells (EACC).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!