At Ohio State University Medical Center, The Honest Broker Protocol provides a streamlined mechanism whereby investigators can obtain de-identified clinical data for non-FDA research without having to invest the significant time and effort necessary to craft a formalized protocol for IRB approval.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Background: Ketone bodies are metabolites produced during fasting or on a ketogenic diet that have pleiotropic effects on the inflammatory and metabolic aging pathways underpinning frailty in models. Ketone esters (KEs) are compounds that induce hyperketonemia without dietary changes and that may impact physical and cognitive function in young adults. The functional effects of KEs have not been studied in older adults.
View Article and Find Full Text PDFDaily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
J Nutr Health Aging
September 2024
Buck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA 94945-1400, USA; Division of Geriatrics, UCSF, 3575 Geary Blvd, Fl 1, San Francisco, CA 94118-3212, USA. Electronic address:
Objectives: Ketone bodies are endogenous metabolites produced during fasting or a ketogenic diet that have pleiotropic effects on aging pathways. Ketone esters (KEs) are compounds that induce ketosis without dietary changes, but KEs have not been studied in an older adult population. The primary objective of this trial was to assess the tolerability and safety of KE ingestion in a cohort of older adults.
View Article and Find Full Text PDFReporting tumor genomic test results to SEER registries via linkages.
J Natl Cancer Inst Monogr
August 2024
Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Article Synopsis
- Precision medicine is increasingly important in cancer care, but tumor genomic data has been lacking in the National Cancer Institute's SEER Program, limiting research on molecular subtypes.
- To improve this, the SEER Program has implemented a centralized process to link cancer cases in their registries with genomic test results from molecular labs, using specialized software and a trusted third party for data handling.
- Recent linkages have included various OncotypeDX tests and results from other genomic classifiers, which facilitate the research community's access to valuable, de-identified data for cancer studies.
NCI SEER-Linked Virtual Tissue Repository Pilot.
J Natl Cancer Inst Monogr
August 2024
Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
Background: The Surveillance, Epidemiology, and End Results (SEER) Program with the National Cancer Institute tested whether population-based cancer registries can serve as honest brokers to acquire tissue and data in the SEER-Linked Virtual Tissue Repository (VTR) Pilot.
Methods: We collected formalin-fixed, paraffin-embedded tissue and clinical data from patients with pancreatic ductal adenocarcinoma (PDAC) and breast cancer (BC) for two studies comparing cancer cases with highly unusual survival (≥5 years for PDAC and ≤30 months for BC) to pair-matched controls with usual survival (≤2 years for PDAC and ≥5 years for BC). Success was defined as the ability for registries to acquire tissue and data on cancer cases with highly unusual outcomes.
What is the role of scientists in meeting the environmental challenges of the twenty-first century?
R Soc Open Sci
June 2024
RSPB Centre for Conservation Science, 2 Lochside View, Edinburgh Park, Edinburgh EH12 9DH, UK.
We live at a time of rapid and accelerating biodiversity loss and climate change that pose an existential risk to the environment, humanity, and social justice and stability. Governmental responses are seen by many citizens, including scientists, as inadequate, leading to an increase in civil protests and activism by those calling for urgent action to effect change. Here we consider the role(s) of scientists in responding to those challenges and engaging with policy given that when a scientist moves into political advocacy, reflecting their values and preferences, their objectivity and the value of scientific opinion may be seen as compromised.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!