Objective: To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.
Methods: Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.
Results: After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.
Conclusion: Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.
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