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Clin Exp Nephrol
January 2025
Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Background: Febuxostat and topiroxostat are non-purine selective xanthine oxidoreductase inhibitors commonly used for hyperuricaemia treatment in Japan. However, comparative data on the effects of febuxostat and topiroxostat on renal function and proteinuria are limited. This study compared proteinuria incidence and changes in the estimated glomerular filtration rate (eGFR) among prevalent febuxostat and topiroxostat users.
View Article and Find Full Text PDFSpine Deform
January 2025
Department of Orthopedic Surgery, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Purpose: Scoliosis is a complex multi-dimensional deformity of the spine that is common in children and adults. Of the various treatments for scoliosis, one is posterior spinal fusion with instrumentation. The rods typically used are composed of titanium or cobalt-chrome.
View Article and Find Full Text PDFAm J Chin Med
January 2025
First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming Yunnan 650500, P. R. China.
Osteoarthritis (OA) is the most common chronic degenerative joint disease, characterized by cartilage damage, synovial inflammation, subchondral bone sclerosis, marginal bone loss, and osteophyte development. Clinical manifestations include inflammatory joint pain, swelling, osteophytes, and limitation of motion. The pathogenesis of osteoarthritis has not yet been fully uncovered.
View Article and Find Full Text PDFBr J Sports Med
January 2025
Division of Preventative Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Objective: To compare physical activity (PA) over midlife between (1) former collegiate athletes and non-athletes and (2) among athletes in different sports.
Methods: The Harvard Alumni Health Study (HAHS) is a prospective cohort study of male undergraduates who completed serial questionnaires regarding PA and health status between 1962 and 1993. PA was categorised by intensity (<3 METs, light; 3 to <6 METs, moderate; ≥6 METs, vigorous), and energy expenditure (kilocalories (kcal)/week) was estimated at each intensity and in total.
BMJ Open
January 2025
Department of Health Sciences, Brunel University of London, Uxbridge, UK
Objective: To investigate the safety, feasibility and acceptability of the Neurofenix platform for upper-limb rehabilitation in acute and subacute stroke.
Design: A feasibility randomised controlled trial with a parallel process evaluation.
Setting: Acute Stroke Unit and participants' homes (London, UK).
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